抗癌药顺铂毒理学研究进展,Chemical Research in Toxicology

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抗癌药顺铂毒理学研究进展
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2019-07-29 00:00:00 , DOI: 10.1021/acs.chemrestox.9b00204
Luyu Qi _{1,

2} , Qun Luo _{1,

2} , Yanyan Zhang ₁ , Feifei Jia ₁ , Yao Zhao ₁ , Fuyi Wang _{1,

2,

3}

Affiliation

顺铂由于其高效和广谱性，是临床上用于各种实体瘤的最广泛使用的化学治疗剂之一。顺铂的抗肿瘤活性主要是由于其与DNA交联的能力，从而阻止了转录和复制。不幸的是，顺铂的临床使用受到其严重的，剂量依赖性的毒副作用的限制。顺铂大约有40种特定毒性，其中肾毒性是最常见的一种。其他常见的副作用包括耳毒性，神经毒性，胃肠道毒性，血液学毒性，心脏毒性和肝毒性。这些副作用共同降低了患者的生活质量，并要求降低药物剂量，甚至停止给药，从而削弱了治疗效果。临床上很少有针对这些副作用的有效措施，因为顺铂引起的各种副作用的确切机制仍不清楚。因此，已经做出了巨大的努力来探索与顺铂毒理学有关的复杂生化过程，旨在确定减少或消除其毒性的有效方法。这篇综述总结并回顾了顺铂毒理学研究的最新进展。我们预期将提供对顺铂副作用潜在机制的理解的洞察力，并设计涉及顺铂的综合治疗策略。为了探索减少或消除顺铂毒性的有效方法，已经做出了巨大的努力来探索涉及顺铂毒理学的复杂生化过程。这篇综述总结并回顾了顺铂毒理学研究的最新进展。我们预期将提供对顺铂副作用潜在机制的理解的洞察力，并设计涉及顺铂的综合治疗策略。为了探索减少或消除顺铂毒性的有效方法，已经做出了巨大的努力来探索涉及顺铂毒理学的复杂生化过程。这篇综述总结并回顾了顺铂毒理学研究的最新进展。我们预期将提供对顺铂副作用潜在机制的理解的洞察力，并设计涉及顺铂的综合治疗策略。

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Advances in Toxicological Research of the Anticancer Drug Cisplatin

Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin is mainly due to its ability to cross-link with DNA, thus blocking transcription and replication. Unfortunately, the clinical use of cisplatin is limited by its severe, dose-dependent toxic side effects. There are approximately 40 specific toxicities of cisplatin, among which nephrotoxicity is the most common one. Other common side effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological toxicity, cardiotoxicity, and hepatotoxicity. These side effects together reduce the life quality of patients and require lowering the dosage of the drug, even stopping administration, thus weakening the treatment effect. Few effective measures exist clinically against these side effects because the exact mechanisms of various side effects from cisplatin remain still unclear. Therefore, substantial effort has been made to explore the complicated biochemical processes involved in the toxicology of cisplatin, aiming to identify effective ways to reduce or eradicate its toxicity. This review summarizes and reviews the updated advances in the toxicological research of cisplatin. We anticipate to provide insights into the understanding of the mechanisms underlying the side effects of cisplatin and designing comprehensive therapeutic strategies involving cisplatin.

更新日期：2019-07-29

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