Metal‐Free Synthesis of 3,4‐Dihydroquinolin‐2(1H)‐Ones Via Cascade Oxidative Decarbonylative Radical Alkylation/Cyclization Of Cinnamamides with Aliphatic Aldehydes,Asian Journal of Organic Chemistry

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Metal‐Free Synthesis of 3,4‐Dihydroquinolin‐2(1H)‐Ones Via Cascade Oxidative Decarbonylative Radical Alkylation/Cyclization Of Cinnamamides with Aliphatic Aldehydes
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2019-08-08 , DOI: 10.1002/ajoc.201900424
Xuemei Xu ₁ , Zaigang Luo ₁ , Chen‐Fu Liu ₂ , Xiuxiu Wang ₁ , Liangdan Deng ₁ , Jie Gao ₁

Affiliation

A practical and efficient method for synthesis of alkyl‐substituted 3,4‐dihydroquinolin‐2(1H)‐ones via cascade oxidative decarbonylative radical alkylation/cyclization of cinnamamides with aliphatic aldehydes under metal‐free conditions was developed. The reaction offers a complementary approach of regioselective intramolecular 6‐endo‐trig cyclization of cinnamamides with various primary, secondary and tertiary alkyl radicals generated from aliphatic aldehydes.

中文翻译：

通过级联氧化脱羰基自由基烷基化/肉桂酰胺与脂肪醛的环化反应，实现无金属合成3,4-二氢喹啉-2（1 H）-一。

开发了一种在无金属条件下通过脂肪酰胺与肉桂酰胺进行级联氧化脱羰基自由基烷基化/环化反应合成烷基取代的3,4-二氢喹啉-2（1 H）-ones的实用有效方法。该反应提供的互补方法区域选择性分子内6-内- TRIG环化由脂肪醛生成的各种伯，仲和叔烷基cinnamamides的。

更新日期：2019-08-08

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