口服硫酸软骨素功能化的纳米颗粒，用于结肠巨噬细胞靶向药物的递送。,Carbohydrate Polymers

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口服硫酸软骨素功能化的纳米颗粒，用于结肠巨噬细胞靶向药物的递送。
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2019-07-26 , DOI: 10.1016/j.carbpol.2019.115126
Xueqing Zhang ₁ , Ya Ma ₁ , Lijun Ma ₂ , Menghang Zu ₃ , Heliang Song ₄ , Bo Xiao ₅

Affiliation

State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Beibei, Chongqing, 400715, PR China; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, Beibei, Chongqing, 400715, PR China.
Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, Beibei, Chongqing, 400715, PR China.
Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Materials and Energy, Southwest University, Beibei, Chongqing, 400715, PR China; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Biotechnology, Southwest University, Beibei, Chongqing, 400715, PR China.
Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, 30303, USA.
State Key Laboratory of Silkworm Genome Biology, School of Materials and Energy, Southwest University, Beibei, Chongqing, 400715, PR China; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Biotechnology, Southwest University, Beibei, Chongqing, 400715, PR China; Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, 30303, USA.

口服靶向消炎药向巨噬细胞的递送已引起极大关注，以最大程度地减少溃疡性结肠炎（UC）的症状。在这项研究中，我们将姜黄素（CUR）封装到聚合物纳米颗粒（NPs）中，并将硫酸软骨素（CS）缀合到它们的表面。所得的CS-NP具有281nm的平均直径，单分散的尺寸分布和带负电的表面。细胞实验表明，这些NPs具有出色的生物相容性，并且在Raw 264.7巨噬细胞中比其对应物（羧甲基纤维素功能化的CUR封装的NPs，CUL-NPs）产生显着更高的细胞内在化效率。而且，与CUL-NPs相比，CS-NPs具有极大的抑制脂多糖刺激的巨噬细胞分泌主要促炎细胞因子分泌的能力。体内实验表明，口服包埋有壳聚糖/藻酸盐水凝胶的CS-NPs与CUL-NPs相比，对UC具有更好的治疗效果。总的来说，我们的结果表明，嵌入CS-NP的水凝胶具有广阔的前景，有望被开发为靶向巨噬细胞的UC治疗药物递送系统。

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更新日期：2019-07-27

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