Ultra-compact miniaturized optical components for microendoscopic tools and miniaturized microscopes are required for minimally invasive imaging. Current microendoscopic technologies used for deep tissue imaging procedures are limited to a large diameter and/or low resolution due to manufacturing restrictions. We demonstrate a platform for miniaturization of an optical imaging system for microendoscopic applications with a resolution of 1 µm. We designed our probe using cascaded micro-lenses and waveguides (lensguide) to achieve a probe as small as 100 µm x 100 µm with a field of view of 60 µm in diameter. We demonstrate wide-field microscopy based on our polymeric probe fabricated using photolithography and a two-photon polymerization process.

中文翻译：

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用于高分辨率深层组织成像的3D微光子探头

微创成像需要用于微型内窥镜工具和微型显微镜的超紧凑型微型光学组件。由于制造限制，用于深部组织成像程序的当前显微内窥镜技术限于大直径和/或低分辨率。我们演示了一个用于微型内窥镜应用的光学成像系统的微型化平台，其分辨率为1 µm。我们使用级联的微透镜和波导（透镜波导）设计了探头，以实现直径100 µm x 100 µm的探头，直径为60 µm。我们展示了基于我们使用光刻和双光子聚合工艺制造的聚合物探针的宽视野显微镜。