Adenosine Triphosphate Templated Self-Assembly of Cationic Porphyrin into Chiral Double Superhelices and Enzyme Mediated Disassembly,Journal of the American Chemical Society

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Adenosine Triphosphate Templated Self-Assembly of Cationic Porphyrin into Chiral Double Superhelices and Enzyme Mediated Disassembly
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-07-22 , DOI: 10.1021/jacs.9b04133
Zhiliang Li _{1,

2} , Charles J Zeman _{1,

2} , Silvano R Valandro ₁ , Jose Paolo O Bantang ₁ , Kirk S Schanze ₁

Affiliation

Self-assembly of small molecules through non-covalent interactions into nanoscale architectures has been extensively studied in supramolecular chemistry. However, it is still challenging to develop a biologically inspired self-assembly system that functions in water with complex structure and dynamics nature by analogy with those found in nature. Here, we report a new water-soluble cationic porphyrin which undergoes adenosine triphosphate (ATP) templated self-assembly into right-handed double-helical supramolecular structures. Direct observation of the porphyrin-ATP assembly by transmission electron microscopy has been accomplished. The assemblies consist of superhelical fibers with length greater than 1 m and width ~ 20 nm. The chiral superhelical fibers show reversible disassembly to monomers upon hydrolysis of ATP when catalyzed by alkaline phosphatase (ALP), and the nanofibers can be reformed with subsequent addition of ATP. Moreover, a transient self-assembly of a chiral double helix is formed when ALP is present to consume ATP.

中文翻译：

三磷酸腺苷模板化阳离子卟啉自组装成手性双超螺旋和酶介导的分解

通过非共价相互作用将小分子自组装成纳米级结构已在超分子化学中得到广泛研究。然而，开发一种受生物学启发的自组装系统仍然具有挑战性，该系统在具有复杂结构和动力学性质的水中发挥作用，类似于自然界中发现的自组装系统。在这里，我们报告了一种新的水溶性阳离子卟啉，它经过三磷酸腺苷 (ATP) 模板化自组装成右手双螺旋超分子结构。通过透射电子显微镜直接观察卟啉-ATP 组装已经完成。组件由长度大于 1 m 和宽度 ~ 20 nm 的超螺旋纤维组成。手性超螺旋纤维在碱性磷酸酶 (ALP) 催化下水解 ATP 后显示出可逆分解为单体，并且纳米纤维可以通过随后添加 ATP 进行重组。此外，当存在 ALP 以消耗 ATP 时，会形成手性双螺旋的瞬时自组装。

更新日期：2019-07-22

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