Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering,Advanced Materials Interfaces

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Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2019-07-22 , DOI: 10.1002/admi.201900761
Tianxue Zhu ₁ , Jiajun Mao ₂ , Yan Cheng ₁ , Haoran Liu ₃ , Lu Lv ₃ , Mingzheng Ge _{1,

4} , Shuhui Li ₂ , Jianying Huang _{2,

5} , Zhong Chen ₆ , Huaqiong Li ₅ , Lei Yang ₇ , Yuekun Lai _{1,

2,

5}

Affiliation

Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

中文翻译：

伤口愈合和组织工程中基于多糖的水凝胶界面的最新进展

多糖是生物相容性和可生物降解的丰富且可复制的天然物质。多糖及其衍生物还具有独特的特性，例如亲水性，机械稳定性以及可调功能。基于多糖的水凝胶可以通过具有不同功能分子的多糖衍生物的物理和/或化学交联来构建，如多孔网络结构或纳米原纤维结构。这篇综述讨论了含有天然多糖，多糖衍生物和多糖复合水凝胶的多糖基水凝胶的生物医学应用。还详细阐述了有关纤维素，壳聚糖，藻酸盐和淀粉基水凝胶的制备，物理性能，先进工程，生物医学应用的最新工作。这种多孔膨胀支架在负压系统如伤口敷料的界面处显示出很大的优势。此外，作者还讨论并总结了这些水凝胶在药物释放，伤口敷料和组织工程应用中的示例性研究工作。最后，讨论了基于多糖的水凝胶开发的挑战和未来前景。

更新日期：2019-07-22

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