Sertoli细胞中的多个信号通路：精子发生的最新发现。,Cell Death & Disease

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Sertoli细胞中的多个信号通路：精子发生的最新发现。
Cell Death & Disease ( IF 8.1 ) Pub Date : 2019-07-17 , DOI: 10.1038/s41419-019-1782-z
Fei-Da Ni ₁ , Shuang-Li Hao ₁ , Wan-Xi Yang ₁

Affiliation

睾丸支持细胞在精子发生中的功能近来引起了越来越多的关注。正常的精子形成依赖于支持细胞，主要是由于它们对营养供应，细胞连接的维持以及对生殖细胞的有丝分裂和减数分裂的支持的影响。在过去的十年中，越来越多的证据突出了精子发生过程中MAPK，AMPK和TGF-β/ Smad信号通路的主要功能。在这些途径中，MAPK信号传导途径调节紧密连接和粘附连接的动态，生殖细胞的增殖和减数分裂，支持细胞的增殖和乳酸产生。AMPK和TGF-β/ Smad信号通路都影响紧密连接和粘附连接的动力学，以及Sertoli细胞的增殖。AMPK信号通路也调节乳酸的供应。这些信号传导途径结合形成一个复杂的精子发生调节网络。在睾丸肿瘤或不育患者中，支持细胞中这些信号通路的活性异常。阐明支持细胞在精子发生过程中的信号通路机制，为理解支持细胞在男性生殖中的生理功能提供了新的见识，同时也是确定异常精子发生的潜在治疗靶点（包括睾丸肿瘤和男性不育症）的先决条件。

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Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis.

The functions of Sertoli cells in spermatogenesis have attracted much more attention recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on nutrient supply, maintenance of cell junctions, and support for germ cells' mitosis and meiosis. Accumulating evidence in the past decade has highlighted the dominant functions of the MAPK, AMPK, and TGF-β/Smad signaling pathways during spermatogenesis. Among these pathways, the MAPK signaling pathway regulates dynamics of tight junctions and adherens junctions, proliferation and meiosis of germ cells, proliferation and lactate production of Sertoli cells; the AMPK and the TGF-β/Smad signaling pathways both affect dynamics of tight junctions and adherens junctions, as well as the proliferation of Sertoli cells. The AMPK signaling pathway also regulates lactate supply. These signaling pathways combine to form a complex regulatory network for spermatogenesis. In testicular tumors or infertile patients, the activities of these signaling pathways in Sertoli cells are abnormal. Clarifying the mechanisms of signaling pathways in Sertoli cells on spermatogenesis provides new insights into the physiological functions of Sertoli cells in male reproduction, and also serves as a pre-requisite to identify potential therapeutic targets in abnormal spermatogenesis including testicular tumor and male infertility.

更新日期：2019-07-18

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