Rapid Base‐ and Metal‐Free Oxidative C‐H Cyclization for the Synthesis of Benzo[4,5]imidazo[1,2‐a]pyridine Derivatives,Asian Journal of Organic Chemistry

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Rapid Base‐ and Metal‐Free Oxidative C‐H Cyclization for the Synthesis of Benzo[4,5]imidazo[1,2‐a]pyridine Derivatives
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2019-07-30 , DOI: 10.1002/ajoc.201900347
Hae Eun Lee ₁ , Mi Jung Lee ₁ , Jin Kyoon Park ₁

Affiliation

Metal‐free oxidative intramolecular cyclizations have been developed for the synthesis of benzo[4,5]imidazo[1,2‐a]pyridines. Remarkably fast reactions were observed when chloramine‐T was used as an oxidant with 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP) as the solvent, and it was noted that the reactions could be performed without using a base at room temperature.

中文翻译：

快速的无碱金属氧化C-H环化反应，合成苯并[4,5]咪唑并[1,2-a]吡啶衍生物

已开发出无金属的氧化性分子内环化方法，用于合成苯并[4,5]咪唑并[1,2- a ]吡啶。当使用氯胺-T作为氧化剂，以1,1,1,1,3,3,3-六氟-2-丙醇（HFIP）作为溶剂时，观察到了显着的快速反应，并且注意到该反应可以在不加溶剂的情况下进行在室温下使用碱。

更新日期：2019-07-30

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