Mucosal-associated invariant T cells and disease.,Nature Reviews Immunology

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Mucosal-associated invariant T cells and disease.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-07-15 , DOI: 10.1038/s41577-019-0191-y
Amine Toubal _{1,

2,

3} , Isabelle Nel _{1,

2,

3} , Sophie Lotersztajn _{2,

3,

4} , Agnès Lehuen _{1,

2,

3}

Affiliation

Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.

中文翻译：

粘膜相关的不变 T 细胞和疾病。

黏膜相关不变 T (MAIT) 细胞是独特的先天样 T 细胞，可连接先天免疫和适应性免疫。它们被源自维生素 B 生物合成的保守细菌配体激活，在防御细菌和病毒感染方面具有重要作用。然而，它们在自身免疫、炎症和代谢疾病中也可能具有各种有害和保护功能。MAIT 细胞参与广泛的病理状况使其成为潜在治疗方法的有吸引力的目标。

更新日期：2019-11-18

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