Natural product derived promising anti-MRSA drug leads: A review.,Bioorganic & Medicinal Chemistry

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Natural product derived promising anti-MRSA drug leads: A review.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2019-07-12 , DOI: 10.1016/j.bmc.2019.07.023
Srikanth Gatadi ₁ , Jitendra Gour ₁ , Srinivas Nanduri ₁

Affiliation

Multi-drug resistant Staphylococcus aureus infections have created a critical need for the development of new classes of antibacterials. Discovery of new naturally derived antibacterial agents with new mechanism of action remains a high priority globally. Several of the available antibacterial agents like β-lactams, polyketides, phenylpropanoids, aminoglycosides, macrolides, glycopeptides, streptogramins and lipopeptides are natural products or their semisynthetic variations. In the current scenario of alarming rise in antibacterial resistance, revisiting natural products with modern chemistry and biology tools has fascinated many medicinal chemists for discovery and development of natural products or derived semisynthetic derivatives as effective antibacterial agents. This review underlines the structures and anti-MRSA activity of various natural product derivatives covering recent reports, in vivo activities and brief Structure Activity Relationships (SARs).

中文翻译：

天然产物衍生的有前途的抗MRSA药物线索：综述。

对多种药物具有耐药性的金黄色葡萄球菌感染已引起对开发新型抗菌剂的迫切需求。具有新的作用机理的新的天然来源的抗菌剂的发现仍然是全球范围内的高度优先事项。几种可用的抗菌剂，例如β-内酰胺，聚酮化合物，苯基丙烷，氨基糖苷类，大环内酯类，糖肽类，链霉菌素类和脂肽类都是天然产物或它们的半合成变体。在当前令人惊奇的抗菌性上升的情况下，用现代化学和生物学工具重新审视天然产物已经使许多药用化学家着迷于发现和开发天然产物或作为有效抗菌剂的衍生的半合成衍生物。

更新日期：2019-07-12

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