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Evaluating the Effect of four Hosting Ionophores on the Performance of Anion Selective Potentiometric Sensor
Electroanalysis ( IF 2.7 ) Pub Date : 2019-07-12 , DOI: 10.1002/elan.201800896 Ahmad S. Saad 1, 2 , Hebatallah M. Essam 1
Electroanalysis ( IF 2.7 ) Pub Date : 2019-07-12 , DOI: 10.1002/elan.201800896 Ahmad S. Saad 1, 2 , Hebatallah M. Essam 1
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A systematically designed practical approach was carried out for the optimization of an anion selective electrode for the determination of an anionic laxative, docusate sodium (DS). The PVC membrane composition and the sensor assembly were systematically optimized. Different sensors were fabricated using tetradodecylammonium bromide (TDAB), tridodecylmethylammonium bromide, tetraheptylammonium bromide as ion exchangers. The effect of ionophore was evaluated using four different host‐guest ionophores, namely; calix[8]arene, β‐cylodextrin, hydroxypropyl‐β‐cylodextrin and carboxymethyl‐β‐cylodextrin to reach the optimum membrane composition. Sensors were constructed in both liquid membrane and solid contact sensor‐assemblies. The slope, linear range, LOQ and response time for each sensor was calculated to assess their performance characteristics. Best Nernstian slope of −61.38 mV/decade and lowest quantification limit of 7.62×10−7 M was achieved by the sensor containing TDAB as ion exchanger and Calix[8]arene as ionophore in the PVC matrix using the gold wire solid contact sensor assembly. Electrode selectivity was assured in the presence of DS potential degradation product, common interfering ions and industrial excipients of tablet and gel formulations. Validation was carried out regarding the ICH validation parameters.
中文翻译：
评估四个寄主离子载体对阴离子选择性电位传感器性能的影响
进行了系统设计的实用方法，以优化用于选择阴离子泻药多库酯钠（DS）的阴离子选择电极。系统地优化了PVC膜的成分和传感器组件。使用四十二烷基溴化铵（TDAB），三十二烷基甲基溴化铵，四庚基溴化铵作为离子交换剂制造了不同的传感器。使用四种不同的宿主客体离子载体评估了离子载体的作用，即：杯[8]芳烃，β-环糊精，羟丙基-β-环糊精和羧甲基-β-环糊精可达到最佳膜组成。传感器既可以在液膜传感器中也可以在固体接触传感器中组装。计算每个传感器的斜率，线性范围，LOQ和响应时间，以评估其性能特征。-7 m为含有作为TDAB离子交换和杯[8]所述传感器取得芳烃如离子载体在使用金线的固体接触传感器组件的PVC基体。在存在DS潜在降解产物，常见干扰离子以及片剂和凝胶制剂的工业赋形剂的情况下，可确保电极选择性。进行了有关ICH验证参数的验证。
更新日期：2019-07-12
中文翻译：
评估四个寄主离子载体对阴离子选择性电位传感器性能的影响
进行了系统设计的实用方法，以优化用于选择阴离子泻药多库酯钠（DS）的阴离子选择电极。系统地优化了PVC膜的成分和传感器组件。使用四十二烷基溴化铵（TDAB），三十二烷基甲基溴化铵，四庚基溴化铵作为离子交换剂制造了不同的传感器。使用四种不同的宿主客体离子载体评估了离子载体的作用，即：杯[8]芳烃，β-环糊精，羟丙基-β-环糊精和羧甲基-β-环糊精可达到最佳膜组成。传感器既可以在液膜传感器中也可以在固体接触传感器中组装。计算每个传感器的斜率，线性范围，LOQ和响应时间，以评估其性能特征。-7 m为含有作为TDAB离子交换和杯[8]所述传感器取得芳烃如离子载体在使用金线的固体接触传感器组件的PVC基体。在存在DS潜在降解产物，常见干扰离子以及片剂和凝胶制剂的工业赋形剂的情况下，可确保电极选择性。进行了有关ICH验证参数的验证。
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