Discovery of Cellular Roles of Intramembrane Proteases.,ACS Chemical Biology

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Discovery of Cellular Roles of Intramembrane Proteases.
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2019-07-24 , DOI: 10.1021/acschembio.9b00404
Hester A Beard ₁ , Marta Barniol-Xicota ₁ , Jian Yang ₁ , Steven H L Verhelst _{1,

2}

Affiliation

Intramembrane proteases (IMPs) are localized within lipid bilayers of membranes-either the cell membrane or membranes of various organelles. Cleavage of substrates often results in release from the membrane, leading to a downstream biological effect. This mechanism allows different signaling events to happen through intramembrane proteolysis. Over the years, various mechanistically distinct families of IMPs have been discovered, but the research progress has generally been slower than for soluble proteases due to the challenges associated with membrane proteins. In this review we summarize how each mechanistic family of IMPs was discovered, which chemical tools are available for the study of IMPs, and which techniques have been developed for the discovery of IMP substrates. Finally, we discuss the various roles in cellular physiology of some of these IMPs.

中文翻译：

发现膜内蛋白酶的细胞作用。

膜内蛋白酶（IMP）位于膜的脂质双层中-细胞膜或各种细胞器的膜中。底物的裂解通常导致从膜中释放出来，从而导致下游生物学效应。这种机制允许通过膜内蛋白水解发生不同的信号事件。多年来，已经发现了各种机理上不同的IMP家族，但是由于与膜蛋白有关的挑战，研究进展通常比可溶性蛋白酶慢。在这篇综述中，我们总结了如何发现IMP的每个机理家族，哪些化学工具可用于IMP的研究，以及开发了哪些技术来发现IMP的底物。最后，

更新日期：2019-07-25

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