Copper‐Promoted Oxidative Intramolecular C–H Amination of Hydrazones to Synthesize 1H‐Indazoles and 1H‐Pyrazoles Using a Cleavable Directing Group,European Journal of Organic Chemistry

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Copper‐Promoted Oxidative Intramolecular C–H Amination of Hydrazones to Synthesize 1H‐Indazoles and 1H‐Pyrazoles Using a Cleavable Directing Group
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2019-07-22 , DOI: 10.1002/ejoc.201900947
Guofu Zhang ₁ , Qiankun Fan ₁ , Yiyong Zhao ₁ , Chengrong Ding ₁

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A facile and efficient copper‐promoted oxidative intramolecular C–H amination of hydrazones for the synthesis of 1H‐indazoles and 1H‐pyrazoles was developed using a tracelessly cleavable directing group. This reaction is characterized by its mild conditions, operational simplicity, readily available reagents, and excellent yields. A tentative mechanism for Cu‐mediated C–H‐oxidative amination was proposed.

中文翻译：

铜促进Hy的分子内氧化CH氨基，使用可裂解的导向基团合成1H-吲唑和1H-吡唑

使用无痕可裂解的导向基团，开发了一种容易且高效的铜促进的azo原子的氧化型分子内CH 3 H胺化反应，用于合成1 H-吲唑和1 H-吡唑。该反应的特征在于其温和的条件，操作简便，易于获得的试剂和优异的收率。提出了一种Cu介导的CHH氧化胺化的初步机制。

更新日期：2019-07-22

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