Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering,Advanced Functional Materials

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Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-07-08 , DOI: 10.1002/adfm.201903279
Yanbo Zhang ₁ , Xiaochen Liu ₂ , Liangdan Zeng ₃ , Jin Zhang ₃ , Jianlin Zuo ₁ , Jun Zou ₄ , Jianxun Ding ₅ , Xuesi Chen ₅

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Successful regeneration of weight‐bearing bone defects and critical‐sized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific‐surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well‐designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering.

中文翻译：

骨和软骨组织工程用聚合物纤维支架

承重骨缺损和临界软骨缺损的成功再生仍然是临床骨科的主要挑战。在过去的几十年中，具有仿生化学和物理特性的可生物降解的聚合物材料已经迅速发展成为骨骼和软骨组织工程支架的理想候选材料。由于其与高比表面积的其他材料相比具有独特的优势，合适的机械强度和可定制的特性，由聚合物纤维制成的支架已越来越多地用于修复骨骼和软骨缺损。这篇综述总结了聚合物纤维的制备和组成，以及它们的特性。更重要的是，具有精心设计的结构或独特特性的聚合物纤维支架在骨骼，软骨，和骨软骨组织工程学已被全面强调。总体而言，这种全面的总结为骨骼和软骨组织工程中聚合物纤维支架的开发提供了建设性的建议。

更新日期：2019-07-08

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