A low cost, flexible, disposable sensing platform which can detect excess ammonia in biological fluids with an enhanced response is of utmost importance in medical diagnostics for early detection of kidney dysfunction, gastrointestinal bleeding, urinary tract related diseases. This report is the first demonstration of direct growth of 2D Tin Diselenide (SnSe₂) on cellulose paper by the hydrothermal method for enhanced photoresponsive ammonia detection in urine samples. X-Ray Diffraction (XRD) and Raman studies confirmed the formation of SnSe2 while field emission scanning electron microscopy (FESEM) studies revealed the uniform distribution of SnSe2 nanoflakes on cellulose paper. The SnSe2 based sensor, when irradiated with Near Infra Red (NIR) light exhibited excellent responsivity, detectivity and external quantum efficiency of 70 mA/W, 11 × 10⁷ jones and 4.5% respectively. Furthermore, the photoresponsive sensor responded to a wide range of ammonia concentrations (50μM - 500μM), with a sensitivity of 0.93 m μM⁻¹ in comparison to 0.73 m μM⁻¹ (without illumination) and a limit of detection (LOD) of 11.3μM which is far more superior in performance than sensors fabricated using sophisticated techniques. Motivated by this enhanced response of the sensor to ammonia in the aqueous medium, it was further employed in detecting ammonia in human urine samples. The mechanism of detection can be attributed to NIR induced oxygen desorption on the surface of 2D- SnSe₂, hence creating more vacant sites for interaction with ammonia molecules. The strategy presented in this work could be a step ahead in developing low cost, point-of-care diagnostics to detect various diseases.

低成本，灵活，可抛弃的传感平台，能够以更快的响应检测出生物液中的过量氨，对于早期诊断肾功能不全，胃肠道出血，泌尿系统相关疾病的医学诊断至关重要。该报告是2D二硒锡（SnSe ₂水热法在纤维素纸上）以增强尿液样品中光敏氨的检测。X射线衍射（XRD）和拉曼研究证实了SnSe2的形成，而场发射扫描电子显微镜（FESEM）研究表明，SnSe2纳米薄片在纤维素纸上的分布均匀。基于SnSe2的传感器在受到近红外（NIR）光照射时表现出出色的响应度，检测率和外部量子效率，分别为70 mA / W，11×10 ⁷琼斯和4.5％。此外，光敏传感器对各种氨浓度（50μM-500μM）有响应，灵敏度为0.93 mμM ^-1，而灵敏度为0.73 mμM ^-1（没有照明）和11.3μM的检测极限（LOD），其性能远远优于使用复杂技术制造的传感器。由于传感器对水性介质中氨的这种增强的响应，促使它进一步用于检测人尿液样品中的氨。检测的机理可以归因于NIR诱导的2D-SnSe ₂表面上的氧解吸，因此产生了更多的空位与氨分子相互作用。这项工作中提出的策略可能是开发低成本，即时诊断的疾病以检测各种疾病的领先一步。