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Disinfection of Infected Root Canals: Nanosilver Has Good Potential
Small Methods ( IF 10.7 ) Pub Date : 2019-07-05 , DOI: 10.1002/smtd.201900378 Wei Yin 1 , Zhong Zheng 2 , Yaoli Liu 1 , Lina Wang 3 , Chun Shi 3 , Lianlian Zhang 4 , Shuo Liu 3 , Weidong Niu 3 , Kang Ting 2 , Zhuan Bian 1
Small Methods ( IF 10.7 ) Pub Date : 2019-07-05 , DOI: 10.1002/smtd.201900378 Wei Yin 1 , Zhong Zheng 2 , Yaoli Liu 1 , Lina Wang 3 , Chun Shi 3 , Lianlian Zhang 4 , Shuo Liu 3 , Weidong Niu 3 , Kang Ting 2 , Zhuan Bian 1
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Bacterial elimination is the key to the treatment of periapical periodontitis. However, existing root canal disinfectants have not fully met this requirement. Here, a new disinfectant candidate, nanosilver, is provided and its efficacy against root canal infection is analyzed. Compared to calcium hydroxide, the nanosilver, which is evenly loaded into the poly(lactic‐co‐glycolic acid) carrier, shows excellent bactericidal activity against free‐living Enterococcus faecalis, stable‐phase E. faecalis biofilm, and starved‐phase E. faecalis biofilm, which is difficult to eliminate through root canal therapy at present. Nanosilver also exhibits great biocompatibility as it does not affect the proliferation of primary pulp cells. In lipopolysaccharide‐triggered periapical periodontitis, the application of nanosilver significantly inhibits the expression of several inflammation‐related factors, including TLR4, Caspase‐1, and Caspase‐11. Furthermore, nanosilver also has a great anti‐inflammatory effect on inhibiting the progression of canine chronic periapical periodontitis. The quantity of E. faecalis in canals and the shadow area around the apex significantly decrease after application of 1% and 2% nanosilver for 4 weeks. It is demonstrated that 1% and 2% nanosilver has a superior ability to resist periapical periodontitis in vivo and in vitro.
中文翻译：
感染根管的消毒：纳米银具有良好的潜力
消除细菌是根尖周周炎治疗的关键。但是，现有的根管消毒剂还不能完全满足这一要求。在这里，提供了一种新的候选消毒剂，纳米银，并分析了其对根管感染的功效。相比氢氧化钙，纳米银，其被均匀地加载到聚（乳酸-共-glycolic酸）的载体，针对自由生活的显示出优异的杀菌活性粪肠球菌，稳定相粪肠球菌生物薄膜，和饥饿相E.粪便生物膜，目前很难通过根管治疗消除。纳米银还表现出很大的生物相容性，因为它不影响原浆细胞的增殖。在脂多糖触发的根尖周周炎中，纳米银的应用显着抑制了几种炎症相关因子的表达，包括TLR4，Caspase-1和Caspase-11。此外，纳米银还具有抑制犬慢性根尖周炎的进展。施用1％和2％的纳米银4周后，粪便中的粪肠球菌数量和根尖周围的阴影区域显着减少。已证明，在体内和体外，1％和2％的纳米银具有优异的抵抗根尖周周炎的能力。
更新日期：2019-07-05
中文翻译：
感染根管的消毒：纳米银具有良好的潜力
消除细菌是根尖周周炎治疗的关键。但是，现有的根管消毒剂还不能完全满足这一要求。在这里，提供了一种新的候选消毒剂，纳米银，并分析了其对根管感染的功效。相比氢氧化钙，纳米银，其被均匀地加载到聚（乳酸-共-glycolic酸）的载体，针对自由生活的显示出优异的杀菌活性粪肠球菌，稳定相粪肠球菌生物薄膜，和饥饿相E.粪便生物膜，目前很难通过根管治疗消除。纳米银还表现出很大的生物相容性，因为它不影响原浆细胞的增殖。在脂多糖触发的根尖周周炎中，纳米银的应用显着抑制了几种炎症相关因子的表达，包括TLR4，Caspase-1和Caspase-11。此外，纳米银还具有抑制犬慢性根尖周炎的进展。施用1％和2％的纳米银4周后，粪便中的粪肠球菌数量和根尖周围的阴影区域显着减少。已证明，在体内和体外，1％和2％的纳米银具有优异的抵抗根尖周周炎的能力。
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