Manipulation of the Geometry and Modulation of the Optical Response of Surfactant-Free Gold Nanostars: A Systematic Bottom-Up Synthesis.,ACS Omega

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Manipulation of the Geometry and Modulation of the Optical Response of Surfactant-Free Gold Nanostars: A Systematic Bottom-Up Synthesis.
ACS Omega ( IF 3.7 ) Pub Date : 2018-02-22 , DOI: 10.1021/acsomega.7b01700
Agampodi S De Silva Indrasekara ₁ , Sean F Johnson ₁ , Ren A Odion ₁ , Tuan Vo-Dinh ₁

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Among plasmonic nanoparticles, surfactant-free branched gold nanoparticles have exhibited exceptional properties as a nanoplatform for a wide variety of applications ranging from surface-enhanced Raman scattering sensing and imaging applications to photothermal treatment and photoimmunotherapy for cancer treatments. The effectiveness and reliability of branched gold nanoparticles in biomedical applications strongly rely on the consistency and reproducibility of physical, chemical, optical, and therapeutic properties of nanoparticles, which are mainly governed by their morphological features. Herein, we present an optimized bottom-up synthesis that improves the reproducibility and homogeneity of the gold-branched nanoparticles with desired morphological features and optical properties. We identified that the order of reagent addition is crucial for improved homogeneity of the branched nature of nanoparticles that enable a high batch-to-batch reproducibility and reliability. In addition, a different combination of the synthesis parameters, in particular, additive halides and concentration ratios of reactive Au to Ag and Au to Au seeds, which yield branched nanoparticle of similar localized surface plasmon resonances but with distinguishable changes in the dimensions of the branches, was realized. Overall, our study introduces the design parameters for the purpose-tailored manufacturing of surfactant-free gold nanostars in a reliable manner.

中文翻译：

无表面活性剂的金纳米星的几何结构和光学响应的调制：系统的自下而上的合成。

在等离子纳米颗粒中，无表面活性剂的支链金纳米颗粒具有优异的性能，可作为纳米平台用于多种应用，从表面增强拉曼散射传感和成像应用到用于癌症治疗的光热处理和光免疫疗法。支链金纳米颗粒在生物医学应用中的有效性和可靠性在很大程度上取决于纳米颗粒的物理，化学，光学和治疗性质的一致性和可重复性，这主要取决于其形态特征。在本文中，我们提出了一种优化的自下而上的合成方法，该方法可改善具有所需形态特征和光学性质的金支化纳米颗粒的重现性和均一性。我们发现，试剂的添加顺序对于提高纳米颗粒支化性质的均质性至关重要，纳米颗粒的支化性质具有很高的批次间可重复性和可靠性。另外，合成参数的不同组合，特别是添加剂卤化物和活性金与银的反应浓度以及金与金的种子的浓度比，可产生具有相似局部等离振子共振但分支尺寸发生明显变化的分支纳米粒子，实现了。总体而言，我们的研究介绍了以可靠的方式针对无表面活性剂的金纳米星量身定制的设计参数。特别是，实现了卤化添加剂和活性金与银的反应以及金与金的种子的浓度比，它们产生了具有相似局部表面等离子体共振的支化纳米粒子，但是支链的尺寸发生了明显变化。总体而言，我们的研究介绍了以可靠的方式针对无表面活性剂的金纳米星量身定制的设计参数。特别是，实现了卤化添加剂和活性金与银的反应以及金与金的种子的浓度比，它们产生了具有相似局部表面等离子体共振的支化纳米粒子，但是支链的尺寸发生了明显变化。总体而言，我们的研究介绍了以可靠的方式针对无表面活性剂的金纳米星量身定制的设计参数。

更新日期：2018-02-22

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