Highly suppressive tumor microenvironments often result in T cell dysfunction and inability to control tumors, but factors regulating this process remain elusive. A new study byMa et al. (2019)reports that tumor cholesterol devitalizes T cells by modulating endoplasmic reticulum stress pathways, revealing a new mechanism underlying T cell exhaustion.

中文翻译：

---

肿瘤胆固醇上升，T细胞下降

高度抑制性的肿瘤微环境通常会导致T细胞功能障碍和无法控制肿瘤，但是调节该过程的因素仍然难以捉摸。Ma等人的一项新研究。（2019）报道肿瘤胆固醇通过调节内质网应激途径使T细胞失活，揭示了T细胞衰竭的新机制。