As one of emerging applications of lab-on-a-chip, microfluidics contribution to pharmaceutical science has arose increasing attention. The demand of lab-on-a-chip technologies for pharmaceutical science led to the development of Pharm-Lab on a Chip, which represents chip-based platforms for whole chain of pharmacy applications from drug discovery to post marketing product management. Pharm-Lab on a Chip may consist of all aspects of chip-based principles, techniques and devices for pharmaceutical analysis, pharmacological/toxicological test and pharmaceutical production. In this review, we focused on the recent advances in utilization of lab-on-a-chip for pharmaceutical analysis and test. The main contents including separation and analysis of drug molecules on a chip, construction of novel pharmacological/toxicological models on a chip, and the application of chip-based models for evaluating drug efficacy and safety. As a summary and prospect, we also try to give insight into the challenges and possible breakthrough of the development of Pharm-Lab on a Chip.

作为芯片实验室的新兴应用之一，微流体对制药科学的贡献已引起越来越多的关注。药物科学上的芯片实验室技术的需求导致了Pharm-Lab on Chip的发展，Pharm-Lab on Chip是代表从药物发现到上市后产品管理的整个制药应用链的基于芯片的平台。Pharm-Lab on Chip可能包含基于芯片的原理，技术和设备的所有方面，用于药物分析，药理/毒理学测试和药物生产。在这篇综述中，我们重点介绍了利用芯片实验室进行药物分析和测试的最新进展。主要内容包括芯片上药物分子的分离和分析，芯片上新型药理/毒理学模型的构建，以及基于芯片的模型在评估药物功效和安全性方面的应用。作为总结和展望，我们还将尝试深入了解Pharm-Lab芯片开发的挑战和可能的突破。