氮化硅：带礼物的生物陶瓷,ACS Applied Materials & Interfaces

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氮化硅：带礼物的生物陶瓷
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2019-06-28 00:00:00 , DOI: 10.1021/acsami.9b07997
Giuseppe Pezzotti _{1,

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Affiliation

在20世纪的最后几十年，氮化硅（Si ₃ N ₄）是为高温燃气轮机应用广泛开发的。技术人员试图利用其卓越的热和机械性能来提高发动机的可靠性和燃油经济性。然而，尽管当时进行了全球研究，但从未实现过这一诺言。尽管令人失望，但在21世纪初它在医疗应用中的使用一直是意想不到的礼物。在保留其所有工程机械性能的同时，它现在还因其独特的表面化学而得到认可。当浸入水性环境中时，从其表面缓慢洗脱出的硅和氮可促进软组织和骨组织的愈合，抑制细菌繁殖并消灭病毒。这些好处使它可以在人体内部和外部的各种不同学科中使用，包括骨科，牙科，病毒学，农学和环境修复。鉴于病毒和细菌的变异造成的全球公共卫生威胁，氮化硅提供了一种有效而直接的替代方法来对抗这些病原体。然而，这些最新发现背后有一个难题：这种独特的生物陶瓷在溶解溶解性病原体的同时如何既对哺乳动物细胞友好呢？这种无与伦比的特性可以通过两种氨（NH）的pH依赖动力学来解释氮化硅提供了一种有效而直接的替代方法来对抗这些病原体。然而，这些最新发现背后有一个难题：这种独特的生物陶瓷在溶解溶解性病原体的同时如何既对哺乳动物细胞友好呢？这种无与伦比的特性可以通过两种氨（NH）的pH依赖动力学来解释氮化硅提供了一种有效而直接的替代方法来对抗这些病原体。然而，这些最新发现背后有一个难题：这种独特的生物陶瓷在溶解溶解性病原体的同时如何既对哺乳动物细胞友好呢？这种无与伦比的特性可以通过两种氨（NH）的pH依赖动力学来解释₄⁺和NH _3-均从湿的Si ₃ N ₄表面浸出。

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Silicon Nitride: A Bioceramic with a Gift

In the closing decades of the 20th century, silicon nitride (Si₃N₄) was extensively developed for high-temperature gas turbine applications. Technologists attempted to take advantage of its superior thermal and mechanical properties to improve engine reliability and fuel economy. Yet, this promise was never realized in spite of the worldwide research, which was conducted at that time. Notwithstanding this disappointment, its use in medical applications in the early 21st century has been an unexpected gift. While retaining all of its engineered mechanical properties, it is now recognized for its peculiar surface chemistry. When immersed in an aqueous environment, the slow elution of silicon and nitrogen from its surface enhances healing of soft and osseous tissue, inhibits bacterial proliferation, and eradicates viruses. These benefits permit it to be used in a wide array of different disciplines inside and outside of the human body including orthopedics, dentistry, virology, agronomy, and environmental remediation. Given the global public health threat posed by mutating viruses and bacteria, silicon nitride offers a valid and straightforward alternative approach to fighting these pathogens. However, there is a conundrum behind these recent discoveries: How can this unique bioceramic be both friendly to mammalian cells while concurrently lysing invasive pathogens? This unparalleled characteristic can be explained by the pH-dependent kinetics of two ammonia species—NH₄⁺ and NH₃—both of which are leached from the wet Si₃N₄ surface.

更新日期：2019-06-28

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