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Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers.
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2019-06-28 , DOI: 10.1016/j.ijbiomac.2019.06.224
Ze-Yu Qin 1 , Xi-Wen Jia 1 , Qian Liu 1 , Bao-Hua Kong 1 , Hao Wang 1
Affiliation  

In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology. The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology, with the increase of chitosan, viscosity and conductivity of solutions increased, the morphology obtained by scanning electron microscopy indicated that the diameter of nanofibers decreased initially then increased. The Fourier transform infrared spectra indicated hydrogen bond interactions between chitosan and pullulan molecules. X-ray diffraction analysis proved that electrospinning process decreased the crystallinity of materials. Thermal analysis showed that melting point, degradation temperature and glass transition temperature increased with the addition of chitosan content in the FDOF. Water solubility test proved that the FDOF can dissolve in water completely within 60 s. Finally, in order to prove its practicability in future, a model drug of aspirin was encapsulated in the FDOF successfully.

中文翻译:

由壳聚糖/普鲁兰静电纺丝纳米纤维制备的用于药物递送的快速溶解口腔膜。

在这项研究中,通过电纺丝技术制备了壳聚糖/普鲁兰复合纳米纤维快速溶解口腔膜(FDOF)。壳聚糖/普鲁兰多糖的比例(C / P)对溶液的性质和纳米纤维的形态有影响,随着壳聚糖含量的增加,溶液的粘度和电导率的增加,扫描电镜观察的形态表明纳米纤维的直径先减小,然后减小。增加。傅立叶变换红外光谱表明壳聚糖和支链淀粉分子之间的氢键相互作用。X射线衍射分析证明,静电纺丝过程降低了材料的结晶度。热分析表明,随着FDOF中壳聚糖含量的增加,熔点,降解温度和玻璃化转变温度均升高。水溶性测试证明,FDOF可以在60 s内完全溶解在水中。最后,为了证明其未来的实用性,将阿司匹林的模型药物成功地封装在FDOF中。
更新日期:2019-06-28
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