Synthesis ( IF 2.2 ) Pub Date : 2019-06-26 , DOI: 10.1055/s-0039-1690101 Xishan Bai 1 , Francesco Aiolfi 1 , Mattia Cettolin 1 , Umberto Piarulli 2 , Alberto Dal Corso 1 , Luca Pignataro 1 , Cesare Gennari 1
Abstract
Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcohols, which had previously been reported to react only in the presence of large amounts of co-catalysts. A range of cyclic and acyclic secondary alcohols were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alcohol group with primary amines to generate saturated N-heterocycles.
Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcohols, which had previously been reported to react only in the presence of large amounts of co-catalysts. A range of cyclic and acyclic secondary alcohols were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alcohol group with primary amines to generate saturated N-heterocycles.
中文翻译:
(环戊二烯酮)铁配合物促进仲醇的氢借胺化
抽象的
得益于高活性催化剂,(环戊二烯酮)铁络合物促进的“氢借”(HB)胺化反应的范围已扩大到仲醇,据报道以前仅在存在大量钴的情况下才发生反应。 -催化剂。使一系列环状和无环仲醇与芳族和脂族胺反应,使取代产物的收率达到相当高的水平。该催化剂还能够促进带有仲醇基的二醇与伯胺的环化反应,生成饱和的N-杂环。
得益于高活性催化剂,(环戊二烯酮)铁络合物促进的“氢借”(HB)胺化反应的范围已扩大到仲醇,据报道以前仅在存在大量钴的情况下才发生反应。 -催化剂。使一系列环状和无环仲醇与芳族和脂族胺反应,使取代产物的收率达到相当高的水平。该催化剂还能够促进带有仲醇基的二醇与伯胺的环化反应,生成饱和的N-杂环。