Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.,Organic Letters

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Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-27 00:00:00 , DOI: 10.1021/acs.orglett.9b01754
Wei-Hua Jiao ₁ , Jing Li _{1,

2} , Meng-Meng Zhang ₃ , Jie Cui ₁ , Yu-Han Gui ₁ , Yun Zhang ₄ , Jing-Ya Li ₃ , Ke-Chun Liu ₄ , Hou-Wen Lin ₁

Affiliation

The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 0.39 μM.

中文翻译：

Frondoplysins A和B，Dysidea frondosa的前所未有的萜烯生物碱生物共轭物。

对海洋海绵Dysidea frondosa的化学研究发现了一对前所未有的生物共轭物，它们由茂金属和一种不寻常的psaplysin生物碱组成。糖蛋白溶菌素A（1）和B（2）的结构通过HRMS和NMR数据分析以及单晶X射线衍射来表征。发现叶绿素A是一种有效的靶向蛋白-酪氨酸磷酸酶1B（PTP1B）的抑制剂，IC ₅₀值为0.39μM。

更新日期：2019-06-27

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