d-Allulose, a C-3 epimer of d-fructose, is a rare sugar reported to be a non-caloric sweetener having several health beneficial effects including anti-hyperglycemia and anti-obesity. However, the impact of dietary d-allulose on cholesterol metabolism remains unclear. Therefore, we studied the effects of d-allulose on the cholesterol metabolism of Golden Syrian hamsters, an animal model with a lipid metabolism similar to that of humans. Hamsters received either normal diet (ND) or high-fat diet (HFD) with or without 3% d-allulose for 4 or 8 weeks. While there were no significant differences in total serum cholesterol levels between the groups, d-allulose significantly increased HDL-cholesterol levels in ND-fed hamsters and decreased LDL-cholesterol levels in HFD-fed hamsters, causing an overall decrease in the LDL/HDL ratio. Furthermore, dietary d-allulose decreased serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels in both diets. In conclusion, d-allulose may favorably modulate cholesterol metabolism by reducing PCSK9 in hamsters.

d -Allulose，的C-3差向异构体d -fructose，是一种罕见糖报道为具有若干健康有益效果包括抗高血糖和抗肥胖症的无热量甜味剂。然而，饮食中的d-阿洛糖对胆固醇代谢的影响尚不清楚。因此，我们研究了d-阿洛糖对金叙利亚仓鼠胆固醇代谢的影响，这是一种脂质代谢与人类相似的动物模型。仓鼠接受普通饮食（ND）或高脂饮食（HFD），含或不含3％d-阿洛糖，持续4或8周。两组之间的总血清胆固醇水平无显着差异，d-阿洛糖显着增加了ND喂养的仓鼠中的HDL-胆固醇水平，并降低了HFD喂养的仓鼠中的LDL-胆固醇水平，从而导致LDL / HDL比值总体下降。此外，饮食中的d-阿洛糖在两种饮食中均降低了血清前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（PCSK9）的水平。总之，d-阿洛糖可以通过减少仓鼠中的PCSK9来有利地调节胆固醇代谢。