A simple and efficient approach has been accomplished for the total synthesis of active pharmaceutical ingredient (API) of Tasimelteon which is effective for treatment of non-24-h sleep-wake disorder. Starting from 4-vinyl-2, 3-dihydrobenzofuran, the synthesis involves asymmetric epoxidation, Wittig reaction, reduction of the nitrile group and propionation of the amine. The synthesis was accomplished in four steps in overall 48% yield.

中文翻译：

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Tasimelteon的全合成

已经完成了一种简单有效的方法来完成Tasimelteon的活性药物成分（API）的总合成，该方法可有效治疗非24小时睡眠-觉醒障碍。从4-乙烯基-2，3-二氢苯并呋喃开始，合成涉及不对称环氧化，Wittig反应，腈基还原和胺的丙酸酯化。合成以四个步骤完成，总产率为48％。