C–H Pyridonation of (Hetero-)Arenes by Pyridinium Radical Cations,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

C–H Pyridonation of (Hetero-)Arenes by Pyridinium Radical Cations
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-26 00:00:00 , DOI: 10.1021/acs.orglett.9b02054
Julius Hillenbrand _{1,

2} , Won Seok Ham _{1,

3} , Tobias Ritter _{1,

2,

3}

Affiliation

Pyridones are important heteroaromatic scaffolds found in natural products and pharmaceuticals and are, therefore, of major interest in organic synthetic chemistry. Here we report the first C–H pyridonation of unactivated (hetero-)arenes, providing a methodology to directly access N-aryl-2- and 4-pyridones. Generation of pyridinium radical cations through single-electron reduction allows for the synthesis of pyridones on structurally complex molecules.

中文翻译：

吡啶基自由基阳离子对（杂）戊烯进行C–H吡啶鎓化

吡啶酮是在天然产物和药物中发现的重要的杂芳族支架，因此，在有机合成化学中引起了人们的极大兴趣。在这里，我们报告了未活化的（杂）芳烃的第一个C–H吡啶化，提供了直接访问N-芳基-2-和4-吡啶酮的方法。通过单电子还原产生吡啶鎓自由基阳离子允许在结构复杂的分子上合成吡啶酮。

更新日期：2019-06-26

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南