Nature Communications ( IF 14.7 ) Pub Date : 2019-06-26 , DOI: 10.1038/s41467-019-10928-0 Dan Wang 1 , Pan Wang 1 , Shengchun Wang 1 , Yi-Hung Chen 1 , Heng Zhang 1 , Aiwen Lei 1
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Alcohol oxidation reactions are widely used for the preparation of aldehydes and ketones. The electrolysis of alcohols to carbonyl compounds have been underutilized owing to low efficiency. Herein, we report an electrochemical oxidation of various alcohols in a continuous-flow reactor without external oxidants, base or mediators. The robust electrochemical oxidation is performed for a variety of alcohols with good functional group tolerance, high efficiency and atom economy, whereas mechanistic studies support the benzylic radical intermediate formation and hydrogen evolution. The electrochemical oxidation proves viable on diols with excellent levels of selectivity for the benzylic position.
中文翻译：
在连续流反应器中，随着氢的释放，直接进行醇的电化学氧化。
醇氧化反应被广泛用于醛和酮的制备。由于效率低，将醇电解成羰基化合物的方法没有得到充分利用。在这里，我们报道了在没有外部氧化剂，碱或介质的情况下，在连续流动反应器中各种醇的电化学氧化。对具有良好官能团耐受性，高效率和原子经济性的各种醇均进行了稳健的电化学氧化，而机理研究则支持苄基自由基中间体的形成和氢的释放。电化学氧化证明对二醇是可行的，并且对苄基位置具有优异的选择性水平。
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