细胞色素c：一种极端的多功能蛋白，在细胞命运中起关键作用。,International Journal of Biological Macromolecules

当前位置： X-MOL 学术 › Int. J. Biol. Macromol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

细胞色素c：一种极端的多功能蛋白，在细胞命运中起关键作用。
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2019-06-25 , DOI: 10.1016/j.ijbiomac.2019.06.180
Roberto Santucci ₁ , Federica Sinibaldi ₁ , Paola Cozza ₁ , Fabio Polticelli ₂ , Laura Fiorucci ₁

Affiliation

细胞色素c是属于c型细胞色素家族1类的蛋白质，其功能取决于细胞定位和工作条件而定。因此，它可以被定义为“极端多功能”蛋白。它介导呼吸链中的电子转移，并作为处理ROS的解毒剂。另外，细胞色素c在细胞凋亡中起作用。释放到细胞质中后，该蛋白与APAF-1结合，激活半胱天冬酶9，并触发导致细胞死亡的酶联级联反应。与构成线粒体膜的磷脂之一心磷脂的相互作用对于启动细胞凋亡是必不可少的。结合部分展开细胞色素c，改变血红素口袋区域，并有助于将Met80从血红素铁的第六个配位位置分离。这些事件将细胞色素c的功能从电子转移穿梭转变为过氧化物酶样血红蛋白，能够触发导致细胞死亡的过程。这篇综述概述了细胞色素c-心磷脂在细胞凋亡中所起的关键作用。这本身不仅很重要，而且还为使用该蛋白质作为生物标记物的临床诊断提供了有趣的观点。

"点击查看英文标题和摘要"

Cytochrome c: An extreme multifunctional protein with a key role in cell fate.

Cytochrome c, a protein that belongs to class 1 of the c-type cytochrome family, exerts different functions depending on its cellular localization and the conditions in which it operates; therefore, it can be defined as 'extreme multifunctional' protein. It mediates electron-transfer in the respiratory chain and acts as a detoxifying agent to dispose of ROS. In addition, cytochrome c plays a role in cell apoptosis. After its release into the cytosol, the protein binds to APAF-1, activates pro-caspase 9, and triggers an enzymatic cascade leading to cell death. The interaction with cardiolipin, one of the phospholipids making up the mitochondrial membrane, is essential to start apoptosis; the binding partially unfolds cytochrome c, alters the heme pocket region, and facilitates detachment of Met80 from the sixth coordination position of the heme iron. These events change the function of cytochrome c from an electron-transfer shuttle to a peroxidase-like hemoprotein, capable to trigger the process that leads to cell death. This review provides an overview of the key role played by the cytochrome c-cardiolipin interaction in apoptosis. This is not only important per se, it provides interesting perspectives for applications in clinical diagnostics that use the protein as a biomarker.

更新日期：2019-06-25

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南