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Sequential Assembly of Mutually Interactive Supramolecular Hydrogels and Fabrication of Multi-Domain Materials.
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-08-01 , DOI: 10.1002/chem.201902158 Carmen C Piras 1 , David K Smith 1
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2019-08-01 , DOI: 10.1002/chem.201902158 Carmen C Piras 1 , David K Smith 1
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A two-component self-sorting hydrogel based on acylhydrazide and carboxylic acid derivatives of 1,3:2,4-dibenzylidene-d-sorbitol (DBS-CONHNH2 and DBS-COOH) is reported. A heating-cooling cycle induces the self-assembly of DBS-CONHNH2 , followed by the self-assembly of DBS-COOH induced by decreasing pH. Although the networks are formed sequentially, there is spectroscopic evidence of interactions between them, which impact on the mechanical properties and significantly enhance the ability of these low-molecular-weight gelators (LMWGs) to form gels when mixed. The DBS-COOH network can be switched "off" and "on" within the two-component gel through a pH change. By using a photo-acid generator, the two-component gel can be prepared combining the thermal trigger with photo-irradiation. Photo-patterned self-assembly of DBS-COOH within a pre-formed DBS-CONHNH2 gel under a mask yields spatially controlled multi-domain gels. Different gel domains can have different functions, for example, controlling the rate of release of heparin incorporated into the gel, or directing gold nanoparticle assembly. Such photo-patterned multi-component hydrogels have potential applications in regenerative medicine or bio-nano-electronics.
中文翻译：
相互作用的超分子水凝胶的顺序组装和多域材料的制备。
报道了基于酰肼和1,3：2,4-二亚苄基-d-山梨糖醇的羧酸衍生物（DBS-CONHNH2和DBS-COOH）的两组分自分选水凝胶。加热-冷却循环诱导DBS-CONHNH2的自组装，然后通过降低pH值诱导DBS-COOH的自组装。尽管网络是顺序形成的，但有光谱证据表明它们之间存在相互作用，这会影响机械性能并显着增强这些低分子量胶凝剂（LMWG）混合时形成凝胶的能力。DBS-COOH网络可通过pH值变化在两组分凝胶内“关闭”和“开启”。通过使用光酸产生剂，可以将热触发与光辐照结合起来制备两组分凝胶。在掩膜下预先形成的DBS-CONHNH2凝胶内，DBS-COOH的光图案化自组装产生了空间控制的多域凝胶。不同的凝胶域可以具有不同的功能，例如，控制掺入凝胶中的肝素的释放速率，或指导金纳米颗粒的组装。这种光图案化的多组分水凝胶在再生医学或生物纳米电子学中具有潜在的应用。
更新日期：2019-08-01
中文翻译：
相互作用的超分子水凝胶的顺序组装和多域材料的制备。
报道了基于酰肼和1,3：2,4-二亚苄基-d-山梨糖醇的羧酸衍生物（DBS-CONHNH2和DBS-COOH）的两组分自分选水凝胶。加热-冷却循环诱导DBS-CONHNH2的自组装，然后通过降低pH值诱导DBS-COOH的自组装。尽管网络是顺序形成的，但有光谱证据表明它们之间存在相互作用，这会影响机械性能并显着增强这些低分子量胶凝剂（LMWG）混合时形成凝胶的能力。DBS-COOH网络可通过pH值变化在两组分凝胶内“关闭”和“开启”。通过使用光酸产生剂，可以将热触发与光辐照结合起来制备两组分凝胶。在掩膜下预先形成的DBS-CONHNH2凝胶内，DBS-COOH的光图案化自组装产生了空间控制的多域凝胶。不同的凝胶域可以具有不同的功能，例如，控制掺入凝胶中的肝素的释放速率，或指导金纳米颗粒的组装。这种光图案化的多组分水凝胶在再生医学或生物纳米电子学中具有潜在的应用。
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