Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity.,Theranostics

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Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity.
Theranostics ( IF 12.4 ) Pub Date : 2019-06-19 , DOI: 10.7150/thno.34337
Marta Tellez-Gabriel ₁ , Marie-Françoise Heymann _{2,

3,

4} , Dominique Heymann _{2,

3,

4}

Affiliation

Tumor heterogeneity is the major cause of failure in cancer prognosis and prediction. Accurately detecting heterogeneity for the development of biomarkers and the detection of the clones resistant to therapy is one of the main goals of contemporary medicine. Metastases belong to the natural history of cancer. The present review gives an overview on the origin of tumor heterogeneity. Recent progress has made it possible to isolate and characterize circulating tumor cells (CTCs), which are the drivers of the disease between the primary sites and metastatic foci. The most recent methods for characterizing CTCs are summarized and we discuss the power of CTC profiling for analyzing tumor heterogeneity in early and advanced diseases.

中文翻译：

循环肿瘤细胞作为评估肿瘤异质性的工具。

肿瘤异质性是癌症预后和预测失败的主要原因。准确检测生物标志物开发的异质性和检测对治疗有抗性的克隆是当代医学的主要目标之一。转移属于癌症的自然史。本综述概述了肿瘤异质性的起源。最近的进展使分离和鉴定循环肿瘤细胞（CTC）成为可能，而循环肿瘤细胞是原发部位和转移灶之间疾病的驱动器。总结了表征CTC的最新方法，我们讨论了CTC分析在分析早期和晚期疾病中的异质性方面的功能。

更新日期：2019-06-24

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