Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans.,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans.
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-19 00:00:00 , DOI: 10.1021/acs.orglett.9b01680
Qin Li ₁ , Chunmei Chen ₁ , Yan He ₂ , Danyingzi Guan ₁ , Li Cheng _{1,

3} , Xincai Hao ₃ , Mengsha Wei ₁ , Yinyu Zheng ₁ , Chang Liu ₁ , Xiao-Nian Li ₄ , Qun Zhou ₁ , Hucheng Zhu ₁ , Yonghui Zhang ₁

Affiliation

Emeriones A–C (1–3), three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities, were isolated from Emericella nidulans. An additional peroxide bridge in compound 3 led to the construction of an unexpected 7,8-dioxatricyclo[4.2.2.0^2,5]decene scaffold. The structures of 1–3 were elucidated by comprehensive spectroscopic techniques, and their absolute configurations were confirmed by single-crystal X-ray crystallographic analyses and ECD calculations. Compound 1 shows weak inhibitory effects on NO production in LPS-induced RAW264.7 cells.

中文翻译：

Emeriones AC：三种高甲基化的聚酮化合物，具有双环[4.2.0]辛烯和3,6-二氧杂双环[3.1.0]己烷官能团的杜鹃花。

Emeriones A-C（1 - 3），三个与二环[4.2.0]辛烯和3,6-二氧杂双环高度甲基化聚酮化合物[3.1.0]己烷的功能，是从分离裸胞壳构巢曲霉。化合物3中的另一个过氧化物桥导致意外的7,8-二氧杂三环[4.2.2.0 ^2,5 ]癸烯骨架的构建。的结构1 - 3通过综合光谱技术阐明，和它们的绝对构型通过单晶X射线晶体分析和ECD的计算证实。在LPS诱导的RAW264.7细胞中，化合物1对NO产生弱的抑制作用。

更新日期：2019-06-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南