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Emeriones A-C: Three Highly Methylated Polyketides with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities from Emericella nidulans.
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-19 00:00:00 , DOI: 10.1021/acs.orglett.9b01680 Qin Li 1 , Chunmei Chen 1 , Yan He 2 , Danyingzi Guan 1 , Li Cheng 1, 3 , Xincai Hao 3 , Mengsha Wei 1 , Yinyu Zheng 1 , Chang Liu 1 , Xiao-Nian Li 4 , Qun Zhou 1 , Hucheng Zhu 1 , Yonghui Zhang 1
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-19 00:00:00 , DOI: 10.1021/acs.orglett.9b01680 Qin Li 1 , Chunmei Chen 1 , Yan He 2 , Danyingzi Guan 1 , Li Cheng 1, 3 , Xincai Hao 3 , Mengsha Wei 1 , Yinyu Zheng 1 , Chang Liu 1 , Xiao-Nian Li 4 , Qun Zhou 1 , Hucheng Zhu 1 , Yonghui Zhang 1
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Emeriones A–C (1–3), three highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane functionalities, were isolated from Emericella nidulans. An additional peroxide bridge in compound 3 led to the construction of an unexpected 7,8-dioxatricyclo[4.2.2.02,5]decene scaffold. The structures of 1–3 were elucidated by comprehensive spectroscopic techniques, and their absolute configurations were confirmed by single-crystal X-ray crystallographic analyses and ECD calculations. Compound 1 shows weak inhibitory effects on NO production in LPS-induced RAW264.7 cells.
中文翻译:
Emeriones AC:三种高甲基化的聚酮化合物,具有双环[4.2.0]辛烯和3,6-二氧杂双环[3.1.0]己烷官能团的杜鹃花。
Emeriones A-C(1 - 3),三个与二环[4.2.0]辛烯和3,6-二氧杂双环高度甲基化聚酮化合物[3.1.0]己烷的功能,是从分离裸胞壳构巢曲霉。化合物3中的另一个过氧化物桥导致意外的7,8-二氧杂三环[4.2.2.0 2,5 ]癸烯骨架的构建。的结构1 - 3通过综合光谱技术阐明,和它们的绝对构型通过单晶X射线晶体分析和ECD的计算证实。在LPS诱导的RAW264.7细胞中,化合物1对NO产生弱的抑制作用。
更新日期:2019-06-19
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
Emeriones AC:三种高甲基化的聚酮化合物,具有双环[4.2.0]辛烯和3,6-二氧杂双环[3.1.0]己烷官能团的杜鹃花。
Emeriones A-C(1 - 3),三个与二环[4.2.0]辛烯和3,6-二氧杂双环高度甲基化聚酮化合物[3.1.0]己烷的功能,是从分离裸胞壳构巢曲霉。化合物3中的另一个过氧化物桥导致意外的7,8-二氧杂三环[4.2.2.0 2,5 ]癸烯骨架的构建。的结构1 - 3通过综合光谱技术阐明,和它们的绝对构型通过单晶X射线晶体分析和ECD的计算证实。在LPS诱导的RAW264.7细胞中,化合物1对NO产生弱的抑制作用。