Pure agarose (AG) hydrogels have strong rigidity and brittleness, which greatly limit their applications. Therefore, in this study, konjac glucomannan (KGM) was used to improve the properties of AG hydrogels. The effect of KGM on the structure and properties of AG hydrogels was investigated by rotational rheometry, Fourier Transform Infrared Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy. The results showed that the flexibility of the composite hydrogels increases with KGM concentration, which may be attributed to a synergistic interaction between KGM and AG resulting in a compact network structure. In vitro drug release behavior of composite hydrogels was investigated under different environments using model drug ciprofloxacin. The results showed that the encapsulation, drug loading efficiencies, and sustained release capacity of AG hydrogels were enhanced by the incorporation of KGM. These results suggested that KGM has the potential to enhance the properties and drug release characteristics of AG hydrogels.

纯琼脂糖（AG）水凝胶具有很强的刚性和脆性，极大地限制了它们的应用。因此，在这项研究中，魔芋葡甘露聚糖（KGM）用于改善AG水凝胶的性能。通过旋转流变仪，傅立叶变换红外光谱，X射线衍射和扫描电子显微镜研究了KGM对AG水凝胶的结构和性能的影响。结果表明，复合水凝胶的柔性随KGM浓度的增加而增加，这可能归因于KGM与AG之间的协同相互作用，从而形成了紧凑的网络结构。体外使用模型药物环丙沙星在不同环境下研究了复合水凝胶的药物释放行为。结果表明，通过加入KGM增强了AG水凝胶的包封，载药效率和缓释能力。这些结果表明，KGM具有增强AG水凝胶的性质和药物释放特性的潜力。