Chicken, duck, egg, and duck egg samples from the Yangtze River Delta and Pearl River Delta regions in China were analyzed for 17 perfluorinated compounds (PFCs). The concentrations of PFCs in chicken and duck livers ranged from <LOD to 35.53 μg/kg and 40.41 μg/kg, respectively, which is higher than in other tissues. PFDA was the predominant PFC in live with mean concentrations of 2.09 μg/kg and 1.73 μg/kg in chicken and duck livers, respectively. The mean ∑PFCs concentrations were 1.87 μg/kg and 1.88 μg/kg in chicken and duck eggs, respectively. The mean PFC concentrations were also similar in the subcutaneous fat of both chicken and duck. The total PFC concentrations in chicken and ducks ranged from <LOD to 54.63 μg/kg and 10.21 μg/kg. The current concentration levels of PFCs would not cause health risks to adults even with the frequent consumption of poultry products. However, the higher concentrations of PFCs in chicken and chicken eggs might cause health risks in children.