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The blood compatibility challenge. Part 1: Blood-contacting medical devices: The scope of the problem.
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-06-18 , DOI: 10.1016/j.actbio.2019.06.021
Iqbal H Jaffer 1 , Jeffrey I Weitz 1
Acta Biomaterialia ( IF 9.4 ) Pub Date : 2019-06-18 , DOI: 10.1016/j.actbio.2019.06.021
Iqbal H Jaffer 1 , Jeffrey I Weitz 1
Affiliation
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Blood-contacting medical devices are an integral part of modern medicine. Such devices may be used for only a few hours or may be implanted for life. Despite advances in biomaterial science, clotting on medical devices remains a common problem. Systemic administration of antiplatelet drugs or anticoagulants is often needed to reduce the risk of clotting. Although effective, such therapy increases the risk of bleeding, which can be fatal. This chapter (a) describes some of the commonly used blood-contacting devices and their potential complications, (b) provides an overview of the mechanisms that drive device-associated clotting, and (c) reviews the strategies employed to attenuate clotting on blood-contacting medical devices. STATEMENT OF SIGNIFICANCE: This paper is part 1 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today.
中文翻译:
血液相容性挑战。第1部分:与血液接触的医疗设备:问题的范围。
血液接触医疗设备是现代医学不可或缺的一部分。此类设备只能使用几个小时,也可以终身植入。尽管生物材料科学取得了进步,但在医疗器械上凝结仍然是一个普遍的问题。通常需要全身性给予抗血小板药物或抗凝剂,以减少凝血的风险。尽管有效,但是这种治疗增加了出血的危险,这可能是致命的。本章(a)描述了一些常用的血液接触设备及其潜在的并发症,(b)概述了驱动与设备相关的凝血的机制,并且(c)概述了用于减弱血液中凝血的策略。联系医疗设备。重要性声明:本文是讨论生物材料相关血栓形成性问题的4篇系列文章的第1部分。目的是突出广泛协议的特征,并对可能引起争议的问题的各个方面进行评论。我们希望,随着新的奖学金解决当今的不确定性,未来的研究者将更新这些评论。
更新日期:2019-06-19
中文翻译:
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血液相容性挑战。第1部分:与血液接触的医疗设备:问题的范围。
血液接触医疗设备是现代医学不可或缺的一部分。此类设备只能使用几个小时,也可以终身植入。尽管生物材料科学取得了进步,但在医疗器械上凝结仍然是一个普遍的问题。通常需要全身性给予抗血小板药物或抗凝剂,以减少凝血的风险。尽管有效,但是这种治疗增加了出血的危险,这可能是致命的。本章(a)描述了一些常用的血液接触设备及其潜在的并发症,(b)概述了驱动与设备相关的凝血的机制,并且(c)概述了用于减弱血液中凝血的策略。联系医疗设备。重要性声明:本文是讨论生物材料相关血栓形成性问题的4篇系列文章的第1部分。目的是突出广泛协议的特征,并对可能引起争议的问题的各个方面进行评论。我们希望,随着新的奖学金解决当今的不确定性,未来的研究者将更新这些评论。