Understanding the Chemical Nature of Nanoparticle-Protein Interactions.,Bioconjugate Chemistry

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Understanding the Chemical Nature of Nanoparticle-Protein Interactions.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2019-07-01 , DOI: 10.1021/acs.bioconjchem.9b00348
Didar Baimanov _{1,

2} , Rong Cai ₁ , Chunying Chen _{1,

2}

Affiliation

The formation of a protein corona has been considered a pitfall in the clinical translation of nanomedicines. Hence, interdisciplinary studies on corona characterization are critically essential. A deep understanding of the formation of hard and soft protein coronas upon in vivo administration of nanoparticles is vital. The protein corona gives the nanoplatform a new biological identity. Furthermore, the control of and mechanistic understanding of corona formation as it is regulated by the physicochemical properties of nanoparticles is crucial for developing safe nanomedicines. A growing number of analytical techniques have been developed in the past decade for examining NP-protein interactions, contributing to a better understanding of protein corona formation on the surface of nanoparticles. In this Review, we summarize the latest developments in the in vivo and in vitro study of dynamic protein corona formation. Insights derived from techniques used to visualize, quantify, and define protein coronas, as well as the methods for examining the kinetics and structural changes of coronal proteins, are discussed. The potential challenges and future perspectives in the study of protein corona formation and its effects on biological behavior and applications of therapeutic nanomaterials are also provided.

中文翻译：

了解纳米粒子-蛋白质相互作用的化学性质。

蛋白质电晕的形成被认为是纳米药物临床翻译中的一个陷阱。因此，关于电晕特性的跨学科研究至关重要。对在体内施用纳米颗粒时硬和软蛋白电晕的形成的深刻理解是至关重要的。蛋白质电晕使纳米平台具有新的生物学特性。此外，对电晕形成的控制和机理理解是受纳米颗粒的理化性质调节的，这对开发安全的纳米药物至关重要。在过去的十年中，已经开发了越来越多的分析技术来检查NP-蛋白质相互作用，从而有助于更好地理解纳米粒子表面上蛋白质电晕的形成。在这篇评论中，我们总结了体内和体外动态蛋白电晕形成研究的最新进展。讨论了从用于可视化，量化和定义蛋白质电晕的技术以及检查冠状蛋白质的动力学和结构变化的方法得出的见解。还提供了蛋白质电晕形成及其对生物学行为的影响以及治疗性纳米材料应用方面的潜在挑战和未来展望。

更新日期：2019-06-17

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