Anthraquinones constitute an important class of natural and synthetic compounds with a broad scope of pharmacological including anti-bacterial, antioxidant, laxative, anti-tumor and other activities. Physcion and physcion 8-O-β-glucopyranoside (PG) are common anthraquinones existed in various plants. Emerging studies suggested that physcion and PG not only exert anti-tumor, anti-microbial, anti-inflammatory, anti-oxidant, optical-related, enzyme inhibitory, lipid regulation and neuroprotective activities, but also lead to hepatotoxicity, renal toxicity and genetic damage. Besides, a growing number of pharmacokinetics researches of physcion and PG also have been conducted. However, no review of physcion or PG have been published by now, so the aim of present review is to give a comprehensive summary and analysis of the pharmacology, toxicity and pharmacokinetics of physcion and PG by consulting all the currently available literatures published in PubMed then give a future prospects about it.

蒽醌构成一类重要的天然和合成化合物，具有广泛的药理作用，包括抗菌，抗氧化剂，泻药，抗肿瘤和其他活性。Physicion和physcion8-O-β-吡喃葡萄糖苷（PG）是多种植物中常见的蒽醌。新兴研究表明，physcion和PG不仅发挥抗肿瘤，抗微生物，抗炎，抗氧化，光学相关，酶抑制，脂质调节和神经保护活性的作用，而且还导致肝毒性，肾脏毒性和遗传损害。此外，对physion和PG的药代动力学研究也越来越多。但是，目前尚未发表有关physcion或PG的综述，因此本综述的目的是对药理学进行全面的总结和分析，