Nickel‐Catalyzed Heck Reaction of Aryl Halides and Terminal Olefins Using Zinc/Triflate Ligand/DMA/TBAB,ChemistrySelect

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Nickel‐Catalyzed Heck Reaction of Aryl Halides and Terminal Olefins Using Zinc/Triflate Ligand/DMA/TBAB
ChemistrySelect ( IF 1.9 ) Pub Date : 2019-06-18 , DOI: 10.1002/slct.201901131
Satyendra Mishra ₁ , Chandni G Halpani ₁ , Sejal Patel ₁

Affiliation

A straightforward and proficient procedure for the nickel‐catalyzed Heck C−C coupling reaction of different aryl halides and with olefins has been accomplished. The reaction, was catalyzed via combination of NiBr2(PPh3)2, zinc powder, additive (BMIM.OTf), K3PO4 as a base in the presence of solvents N,N‐dimethylacetamide (DMA) and Tetra‐n‐butylammonium bromide(TBAB). The arylation of methyl acrylate and styrene with various aryl iodides under optimized catalytic systems, showed excellent yield of the products. Remarkably, base (K3PO4), additive (BMIM.OTf) and the solvent (TBAB/DMA) have shown an indispensable effects on the efficacy of the reaction and it has been found to be in most favorable condition for heck reaction.

中文翻译：

锌/三氟配体/ DMA / TBAB的镍催化芳基卤化物和末端烯烃的Heck反应

已经完成了一种直接且有效的方法，用于不同芳基卤化物以及与烯烃的镍催化的Heck C-C偶联反应。在溶剂N，N-二甲基乙酰胺（DMA）和四正丁基溴化铵（TBAB）存在下，通过NiBr2（PPh3）2，锌粉，添加剂（BMIM.OTf），K3PO4作为碱的组合催化反应）。在优化的催化体系下，丙烯酸甲酯和苯乙烯与各种芳基碘化物的芳基化反应显示出优异的产物收率。值得注意的是，碱（K3PO4），添加剂（BMIM.OTf）和溶剂（TBAB / DMA）对反应效率显示出必不可少的影响，并且发现该化合物处于最适合进行ck反应的条件下。

更新日期：2019-06-18

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