聚合物水溶性活化酯：合成带有侧链 N-羟基磺基琥珀酰亚胺酯的聚合物主链，用于在水中进行聚合后改性,Polymer Journal

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聚合物水溶性活化酯：合成带有侧链 N-羟基磺基琥珀酰亚胺酯的聚合物主链，用于在水中进行聚合后改性
Polymer Journal ( IF 2.3 ) Pub Date : 2019-06-18 , DOI: 10.1038/s41428-019-0221-4
Sotaro Tsuji , Yuji Aso , Hitomi Ohara , Tomonari Tanaka

使用带有 N-羟基磺基琥珀酰亚胺 (sulfoNHS) 酯的丙烯酰胺衍生物作为单体底物，通过可逆加成-断裂链转移 (RAFT) 聚合技术合成具有水溶性活化酯侧基的新型聚合物主链。通过N-羟基磺基琥珀酰亚胺钠盐与6-丙烯酰胺基己酸的脱水缩合反应，新合成了带有磺基NHS酯的单体。RAFT 聚合机理很好地控制了所得聚合物的分子量和多分散指数。为了合成糖聚合物，在水中用含胺的糖衍生物对氨基苯基 β-d-吡喃半乳糖苷 (pAP-Gal) 取代聚合物侧链上的 sulfoNHS 酯。得到的带有 pAP-Gals 的糖聚合物与水溶液中相应的凝集素花生凝集素表现出强烈的相互作用，因为糖部分是多价的。 ) 使用带有 N-羟基磺基琥珀酰亚胺 (sulfoNHS) 酯的丙烯酰胺衍生物作为单体底物的聚合技术。为了合成糖聚合物，聚合物侧链上的 sulfoNHS 酯与含胺的糖类衍生物的取代反应在水中进行。所得的糖聚合物与水溶液中的相应凝集素表现出强烈的相互作用，因为糖部分是多价的。

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Polymeric water-soluble activated esters: synthesis of polymer backbones with pendant N-hydoxysulfosuccinimide esters for post-polymerization modification in water

Novel polymer backbones with water-soluble activated ester pendant groups were synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization technique using an acrylamide derivative bearing an N-hydroxysulfosuccinimide (sulfoNHS) ester as a monomer substrate. The monomer bearing a sulfoNHS ester was newly synthesized by a dehydrative condensation reaction of N-hydroxysulfosuccinimide sodium salt with 6-acrylamidohexanoic acid. The molecular weight and polydispersity indexes of the resulting polymers were well controlled by the RAFT polymerization mechanism. To synthesize glycopolymers, the substitution of the sulfoNHS esters on the polymer side chain with an amine-containing saccharide derivative, p-aminophenyl β-d-galactopyranoside (pAP-Gal), was performed in water. The resulting glycopolymer bearing pAP-Gals exhibited a strong interaction with the corresponding lectin peanut agglutinin in aqueous solution, because the saccharide moieties are multivalent.Novel polymer backbones with pendant water-soluble activated esters were synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization technique using an acrylamide derivative bearing an N-hydroxysulfosuccinimide (sulfoNHS) ester as a monomer substrate. To synthesize glycopolymers, the substitution reaction at the sulfoNHS esters on the polymer side chain with an amine-containing saccharide derivative was performed in water. The resulting glycopolymer exhibited a strong interaction with the corresponding lectin in aqueous solution, because the saccharide moieties are multivalent.

更新日期：2019-06-18

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