Z‐bpy, a New C2‐Symmetric Bipyridine Ligand and Its Application in Enantioselective Copper(I)‐Catalyzed Cyclopropanation of Olefins,Chinese Journal of Chemistry

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Z‐bpy, a New C2‐Symmetric Bipyridine Ligand and Its Application in Enantioselective Copper(I)‐Catalyzed Cyclopropanation of Olefins
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2019-06-20 , DOI: 10.1002/cjoc.201900141
Yizhao Ouyang ₁ , Miao Zhan ₁ , Jing Zhou ₁ , Jiao Jiao _{2,

3} , Hao Hu ₄ , Yoichi M. A. Yamada ₄ , Pengfei Li _{1,

3}

Affiliation

A rigid C₂‐symmetric chiral bipyridine ligand Z‐bpy with a triptycene‐like backbone was designed and synthesized from simple chemicals in a scalable route. Using this new ligand, copper(I) catalyzed cyclopropanation of styrenes with commercial ethyl diazoacetate produced various corresponding cyclopropanes in high yields, diastereoselectivity and enantioselectivity up to 97% ee.

中文翻译：

一种新型的C2对称联吡啶配体Z-bpy及其在对映体铜（I）催化的烯烃环丙烷化中的应用

设计了刚性的C ₂对称手性联吡啶配体Z-bpy，具有三萜类骨架，并通过简单的化学方法以可扩展的方式合成。使用这种新的配体，铜（I）与市售重氮乙酸乙酯催化苯乙烯的环丙烷化反应可高产率，非对映选择性和对映选择性高达97％ee生成各种相应的环丙烷。

更新日期：2019-06-20

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