Reversing Chemoselectivity: Simultaneous Positive and Negative Catalysis by Chemically Equivalent Rims of a Cucurbit[7]uril Host,Angewandte Chemie International Edition

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Reversing Chemoselectivity: Simultaneous Positive and Negative Catalysis by Chemically Equivalent Rims of a Cucurbit[7]uril Host
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-07-11 , DOI: 10.1002/anie.201905027
Nazar Rad ₁ , Oksana Danylyuk ₁ , Volodymyr Sashuk ₁

Affiliation

Enzyme catalysis has always been an inspiration and an unattainable goal for chemists due to features such as high specificity, selectivity, and efficiency. Here, we disclose a feature neither common in enzymes nor ever described for enzyme mimics, but one that could prove crucial for the catalytic performance of the latter, namely the ability to catalyze and inhibit two different reactions at the same time. Remarkably, this can be realized by two identical, spatially resolved catalytic sites. In the future, such a synchronized catalyst action could be used not only for controlling chemoselectivity, as in the present case, but also for regulating other types of chemical reactivity.

中文翻译：

逆向化学选择性：葫芦[7] uril主体的化学当量环同时进行正负催化

由于具有高特异性，选择性和高效率等特点，酶催化一直是化学家的灵感和无法实现的目标。在这里，我们公开了一种既不存在于酶中也未描述过的酶模拟物的特征，但是可以证明对后者的催化性能至关重要的一个特征，即同时催化和抑制两种不同反应的能力。值得注意的是，这可以通过两个相同的，空间分辨的催化位点来实现。将来，这种同步的催化剂作用不仅可以用于控制化学选择性，如目前的情况，还可以用于调节其他类型的化学反应性。

更新日期：2019-07-11

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