Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.,Nature Neuroscience

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Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-06-17 , DOI: 10.1038/s41593-019-0421-4
Kristina Valentinova _{1,

2} , Anna Tchenio ₁ , Massimo Trusel ₁ , Joseph A Clerke ₁ , Arnaud L Lalive ₁ , Stamatina Tzanoulinou ₃ , Alessandro Matera ₄ , Imane Moutkine ₅ , Luc Maroteaux ₅ , Rosa C Paolicelli ₄ , Andrea Volterra ₁ , Camilla Bellone ₃ , Manuel Mameli _{1,

5}

Affiliation

The lateral habenula encodes aversive stimuli contributing to negative emotional states during drug withdrawal. Here we report that morphine withdrawal in mice leads to microglia adaptations and diminishes glutamatergic transmission onto raphe-projecting lateral habenula neurons. Chemogenetic inhibition of this circuit promotes morphine withdrawal-like social deficits. Morphine withdrawal-driven synaptic plasticity and reduced sociability require tumor necrosis factor-α (TNF-α) release and neuronal TNF receptor 1 activation. Hence, habenular cytokines control synaptic and behavioral adaptations during drug withdrawal.

中文翻译：

吗啡戒断者募集侧ha肌细胞因子信号传导，以减少突触兴奋性和社交能力。

外侧ha管编码厌恶性刺激，在戒断药物时会导致负面的情绪状态。在这里，我们报告小鼠吗啡戒断导致小胶质细胞适应和减少谷氨酸能传递到投射到羊phe侧lateral神经元上。该回路的化学生成抑制作用促进了吗啡戒断样社会缺陷。吗啡戒断驱动的突触可塑性和降低的社交能力要求释放肿瘤坏死因子-α（TNF-α）和激活神经元TNF受体1。因此，在停药期间，唇形细胞因子控制突触和行为适应。

更新日期：2019-06-17

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