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The combination of hawthorn extract and camphor significantly increases blood pressure: A meta-analysis and systematic review.
Phytomedicine ( IF 6.7 ) Pub Date : 2019-06-12 , DOI: 10.1016/j.phymed.2019.152984 Dezső Csupor 1 , Réka Viczián 2 , Tamás Lantos 3 , Tivadar Kiss 1 , Péter Hegyi 4 , Judit Tenk 5 , László Márk Czumbel 6 , Sang-Ngoen Thanyaporn 6 , Zoltán Gyöngyi 7 , Gábor Varga 6 , Gábor Gerber 8 , Erika Pétervári 5 , Barbara Tóth 1
Phytomedicine ( IF 6.7 ) Pub Date : 2019-06-12 , DOI: 10.1016/j.phymed.2019.152984 Dezső Csupor 1 , Réka Viczián 2 , Tamás Lantos 3 , Tivadar Kiss 1 , Péter Hegyi 4 , Judit Tenk 5 , László Márk Czumbel 6 , Sang-Ngoen Thanyaporn 6 , Zoltán Gyöngyi 7 , Gábor Varga 6 , Gábor Gerber 8 , Erika Pétervári 5 , Barbara Tóth 1
Affiliation
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BACKGROUND
A fixed combination of hawthorn and camphor (Korodin Herz-Kreislauf-Tropfen®) has been used in the therapy of hypotension for decades. Although its efficacy was evaluated in clinical trials, these studies have not been critically assessed in meta-analyses.
PURPOSE
To systematically evaluate the efficacy of a fix combination of camphor and hawthorn extract (Korodin®) on blood pressure and cognition compared to placebo, in a meta-analysis based on randomized controlled trials (RCTs).
STUDY DESIGN
The meta-analysis was carried out following the PRISMA guidelines, using the PICO format, and it was registered in the PROSPERO register.
METHODS
The Cochrane Central Register of Controlled Trials, PubMed, Embase, and Web of Science databases were searched for relevant studies. Placebo-controlled clinical studies involving adult patients receiving a fix combination of hawthorn extract and camphor were included. No language or publication year restrictions were applied.
RESULTS
Four randomized trials including a total of 221 patients were pooled for statistical analysis. According to the present meta-analysis, the fixed combination of hawthorn and camphor significantly increases systolic and diastolic blood pressure compared to placebo (p-values: 0.017 and 0.049, respectively) and had a beneficial, but not statistically significant effect on the cognitive performance in the connect-the-numbers test (p-value: 0.071).
CONCLUSION
Korodin® is an effective and presumably safe complementary therapy for the treatment of hypotension. Its blood pressure increasing effect is confirmed; however, the evidence supporting its use is very limited. The optimum dose and duration of treatment is still unclear. The comprehensive evaluation of efficacy and safety is required in further, high-quality clinical studies, involving larger patient populations and comparable endpoints.
中文翻译：
山楂提取物和樟脑的组合可显着提高血压：一项荟萃分析和系统评价。
背景技术山楂和樟脑的固定组合（Korodin Herz-Kreislauf-Tropfen）已用于低血压的治疗数十年。尽管其功效已在临床试验中进行了评估，但尚未在荟萃分析中对这些研究进行严格的评估。目的在一项基于随机对照试验（RCT）的荟萃分析中，系统地评估樟脑和山楂提取物（Korodin®）的固定组合与安慰剂相比对血压和认知的功效。研究设计荟萃分析是按照PRISMA指南进行的，采用PICO格式，并已在PROSPERO寄存器中注册。方法检索Cochrane对照试验中央注册系统，PubMed，Embase和Web of Science数据库，以进行相关研究。包括安慰剂对照的临床研究，涉及接受山楂提取物和樟脑固定组合治疗的成年患者。没有语言或出版年份的限制。结果汇总了四项随机试验，共221例患者，进行了统计分析。根据目前的荟萃分析，山楂和樟脑的固定组合与安慰剂相比显着增加了收缩压和舒张压（p值分别为0.017和0.049），并且对认知表现有有益但无统计学意义的影响在数字连接测试中（p值：0.071）。结论Korodin®是治疗低血压的有效且大概安全的补充疗法。证实了它的血压升高作用；然而，支持其使用的证据非常有限。最佳剂量和治疗持续时间仍不清楚。进一步的高质量临床研究需要对疗效和安全性进行全面评估，涉及更多的患者人群和可比较的终点。
更新日期：2019-06-12
中文翻译：
山楂提取物和樟脑的组合可显着提高血压：一项荟萃分析和系统评价。
背景技术山楂和樟脑的固定组合（Korodin Herz-Kreislauf-Tropfen）已用于低血压的治疗数十年。尽管其功效已在临床试验中进行了评估，但尚未在荟萃分析中对这些研究进行严格的评估。目的在一项基于随机对照试验（RCT）的荟萃分析中，系统地评估樟脑和山楂提取物（Korodin®）的固定组合与安慰剂相比对血压和认知的功效。研究设计荟萃分析是按照PRISMA指南进行的，采用PICO格式，并已在PROSPERO寄存器中注册。方法检索Cochrane对照试验中央注册系统，PubMed，Embase和Web of Science数据库，以进行相关研究。包括安慰剂对照的临床研究，涉及接受山楂提取物和樟脑固定组合治疗的成年患者。没有语言或出版年份的限制。结果汇总了四项随机试验，共221例患者，进行了统计分析。根据目前的荟萃分析，山楂和樟脑的固定组合与安慰剂相比显着增加了收缩压和舒张压（p值分别为0.017和0.049），并且对认知表现有有益但无统计学意义的影响在数字连接测试中（p值：0.071）。结论Korodin®是治疗低血压的有效且大概安全的补充疗法。证实了它的血压升高作用；然而，支持其使用的证据非常有限。最佳剂量和治疗持续时间仍不清楚。进一步的高质量临床研究需要对疗效和安全性进行全面评估，涉及更多的患者人群和可比较的终点。
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