关于双酚A（BPA）结构类似物和功能替代品的健康和毒理活性的范围概述。,Toxicology

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关于双酚A（BPA）结构类似物和功能替代品的健康和毒理活性的范围概述。
Toxicology ( IF 4.8 ) Pub Date : 2019-06-12 , DOI: 10.1016/j.tox.2019.06.006
Katherine Pelch ₁ , Jessica A Wignall ₂ , Alexandra E Goldstone ₂ , Pam K Ross ₂ , Robyn B Blain ₂ , Andrew J Shapiro ₁ , Stephanie D Holmgren ₃ , Jui-Hua Hsieh ₁ , Daniel Svoboda ₄ , Scott S Auerbach ₁ , Fredrick M Parham ₁ , Scott A Masten ₁ , Vickie Walker ₁ , Andrew Rooney ₁ , Kristina A Thayer ₁

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最新研究报告称，广泛使用或接触与双酚A（BPA）具有结构或功能相似性的多种化学物质，称为BPA类似物或衍生物。这些已在食品，房屋灰尘，环境样品，人类尿液或血液以及消费产品中检测到。与双酚A相比，对这些化合物的潜在毒性了解得很少。这项范围界定性综述旨在总结研究和监管机构正在兴起的24种BPA类似物的人，动物和机械毒性数据。在2015年3月1日至2019年1月5日期间对PubMed进行了搜索，并将其与在2015年3月23日进行的文献搜索所获得的结果相结合，在《美国国家毒理学计划》的研究报告4（NTP RR-04）中，“ 和氧化应激。但是，很少有研究针对诸如神经发育结局或对发育中的乳腺或前列腺的影响等端点进行研究，这些端点已知容易受到BPA的破坏。此外，仍然迫切需要更好的暴露信息，以便优先进行实验研究。展望未来，研究人员还应确保对所有主要作用均进行全剂量反应，以支持危害和风险表征工作。这里收集的证据表明，危害和风险特征应扩展到BPA以外，以便考虑BPA的结构和功能类似物。已知容易被BPA破坏。此外，仍然迫切需要更好的暴露信息，以便优先进行实验研究。展望未来，研究人员还应确保对所有主要作用均进行全剂量反应，以支持危害和风险表征工作。这里收集的证据表明，危害和风险特征应扩展到BPA以外，以便考虑BPA的结构和功能类似物。已知容易被BPA破坏。此外，仍然迫切需要更好的暴露信息，以便优先进行实验研究。展望未来，研究人员还应确保对所有主要作用均进行全剂量反应，以支持危害和风险表征工作。这里收集的证据表明，危害和风险特征应扩展到BPA以外，以便考虑BPA的结构和功能类似物。

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A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.

Recent studies report widespread usage or exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine or blood, and consumer products. Compared to BPA, relatively little is known about potential toxicity of these compounds. This scoping review aimed to summarize the human, animal, and mechanistic toxicity data for 24 BPA analogues of emerging interest to research and regulatory communities. PubMed was searched from March 1, 2015 to January 5, 2019 and combined with the results obtained from literature searches conducted through March 23, 2015, in The National Toxicology Program's Research Report 4 (NTP RR-04), "Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives". Study details are presented in interactive displays using Tableau Public. In total, 5748 records were screened for inclusion. One hundred sixty seven studies were included from NTP RR-04 and 175 studies were included from the updated literature search through January 2019. In total, there are 22, 117, and 221 human epidemiological, experimental animal, or in vitro studies included. The most frequently studied BPA analogues are bisphenol S (BPS), bisphenol F (4,4-BPF), and bisphenol AF (BPAF). Notable changes in the literature since 2015 include the growing body of human epidemiological studies and in vivo studies conducted in zebrafish. Numerous new endpoints were also evaluated across all three evidence streams including diabetes, obesity, and oxidative stress. However, few studies have addressed endpoints such as neurodevelopmental outcomes or impacts on the developing mammary or prostate glands, which are known to be susceptible to disruption by BPA. Further, there remains a critical need for better exposure information in order to prioritize experimental studies. Moving forward, researchers should also ensure that full dose responses are performed for all main effects in order to support hazard and risk characterization efforts. The evidence gathered here suggests that hazard and risk characterizations should expand beyond BPA in order to consider BPA structural and functional analogues.

更新日期：2019-06-12

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