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Photochemical Amplifier Based on Self-Immolative Dendritic Spacers
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-06-11 00:00:00 , DOI: 10.1021/acs.joc.9b00651 Agonist Kastrati 1 , Christian G. Bochet 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-06-11 00:00:00 , DOI: 10.1021/acs.joc.9b00651 Agonist Kastrati 1 , Christian G. Bochet 1
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A self-immolative dendritic structure was synthesized. It is based on phenol derivatives with three hydroxymethyl arms at both ortho and para positions of the core unit, potentially releasing up to 27 leaving groups in a third-generation dendrimer. The triggering event is the photolysis of a photosentive ortho-nitrobenzyl group. In doing so, we expected to transform a weak chemical or photochemical input into a large chemical output, which fulfills the definition of a molecular amplifier. Such dendrimers could find application as an indicator, a drug-delivery vector, or a solubilizing agent. The prepared dendrimer indeed released up to 27 leaving groups upon photolysis at 360 nm.
中文翻译：
基于自消灭的树枝状间隔基的光化学放大器
合成了自消灭的树枝状结构。它基于在核心单元的邻位和对位均具有三个羟甲基臂的酚衍生物，可能在第三代树状聚合物中释放多达27个离去基团。触发事件是光敏性邻硝基硝基苄基的光解。通过这样做，我们期望将弱化学或光化学输入转换为大化学输出，从而满足分子放大器的定义。这样的树枝状聚合物可以用作指示剂，药物递送载体或增溶剂。制备的树枝状大分子确实在360 nm光解时释放了多达27个离去基团。
更新日期：2019-06-11
中文翻译：
基于自消灭的树枝状间隔基的光化学放大器
合成了自消灭的树枝状结构。它基于在核心单元的邻位和对位均具有三个羟甲基臂的酚衍生物，可能在第三代树状聚合物中释放多达27个离去基团。触发事件是光敏性邻硝基硝基苄基的光解。通过这样做，我们期望将弱化学或光化学输入转换为大化学输出，从而满足分子放大器的定义。这样的树枝状聚合物可以用作指示剂，药物递送载体或增溶剂。制备的树枝状大分子确实在360 nm光解时释放了多达27个离去基团。
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