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Controlled Co-delivery of Growth Factors through Layer-by-Layer Assembly of Core-Shell Nanofibers for Improving Bone Regeneration.
ACS Nano ( IF 15.8 ) Pub Date : 2019-06-11 00:00:00 , DOI: 10.1021/acsnano.8b06032 Gu Cheng 1 , Chengcheng Yin 1 , Hu Tu 2 , Shan Jiang 3 , Qun Wang 4 , Xue Zhou 5 , Xin Xing 1 , Congyong Xie 1 , Xiaowen Shi 2 , Yuming Du 2 , Hongbing Deng 2 , Zubing Li 1
ACS Nano ( IF 15.8 ) Pub Date : 2019-06-11 00:00:00 , DOI: 10.1021/acsnano.8b06032 Gu Cheng 1 , Chengcheng Yin 1 , Hu Tu 2 , Shan Jiang 3 , Qun Wang 4 , Xue Zhou 5 , Xin Xing 1 , Congyong Xie 1 , Xiaowen Shi 2 , Yuming Du 2 , Hongbing Deng 2 , Zubing Li 1
Affiliation
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The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth factors which are expressed in a coordinated cascade of events. The aim of this study was to create a dual growth factor-release system that allows for time-controlled release to facilitate bone regeneration. We fabricated core–shell SF/PCL/PVA nanofibrous mats using coaxial electrospinning and layer-by-layer (LBL) techniques, where bone morphogenetic protein 2 (BMP2) was incorporated into the core of the nanofibers and connective tissue growth factor (CTGF) was attached onto the surface. Our study confirmed the sustained release of BMP2 and a rapid release of CTGF. Both in vitro and in vivo experiments demonstrated improvements in bone tissue recovery with the dual-drug release system. In vivo studies showed improvement in bone regeneration by 43% compared with single BMP2 release systems. Time-controlled release enabled by the core–shell nanofiber assembly provides a promising strategy to facilitate bone healing.
中文翻译：
通过层层组装核-壳纳米纤维来提高骨再生的生长因子的受控共传递。
骨组织的再生受成骨生长因子和血管生成生长因子的调节，它们以协调的事件级联表达。这项研究的目的是创建一个双重生长因子释放系统，该系统允许时间控制释放以促进骨骼再生。我们使用同轴静电纺丝和逐层（LBL）技术制造了核-壳SF / PCL / PVA纳米纤维垫，其中骨形态发生蛋白2（BMP2）被掺入纳米纤维的核心和结缔组织生长因子（CTGF）被附着在表面上。我们的研究证实了BMP2的持续释放和CTGF的快速释放。二者在体外和体内骨组织恢复实验证实的改进与双药物释放系统。体内研究表明，与单一BMP2释放系统相比，骨骼再生提高了43％。核-壳纳米纤维组件实现的时间控制释放提供了促进骨愈合的有前途的策略。
更新日期：2019-06-11
中文翻译：
通过层层组装核-壳纳米纤维来提高骨再生的生长因子的受控共传递。
骨组织的再生受成骨生长因子和血管生成生长因子的调节，它们以协调的事件级联表达。这项研究的目的是创建一个双重生长因子释放系统，该系统允许时间控制释放以促进骨骼再生。我们使用同轴静电纺丝和逐层（LBL）技术制造了核-壳SF / PCL / PVA纳米纤维垫，其中骨形态发生蛋白2（BMP2）被掺入纳米纤维的核心和结缔组织生长因子（CTGF）被附着在表面上。我们的研究证实了BMP2的持续释放和CTGF的快速释放。二者在体外和体内骨组织恢复实验证实的改进与双药物释放系统。体内研究表明，与单一BMP2释放系统相比，骨骼再生提高了43％。核-壳纳米纤维组件实现的时间控制释放提供了促进骨愈合的有前途的策略。
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