Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?,ChemBioChem

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Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
ChemBioChem ( IF 2.6 ) Pub Date : 2019-08-08 , DOI: 10.1002/cbic.201900249
Rebecca L Tarnopol ₁ , Sierra Bowden ₁ , Kevin Hinkle ₁ , Krithika Balakrishnan ₁ , Akira Nishii ₁ , Caleb J Kaczmarek ₁ , Tara Pawloski ₁ , Anthony G Vecchiarelli ₁

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One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self-organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self-organizing principles of a living cell and how these self-organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents.

中文翻译：

最小基因组的教训：从头开始构建细胞的基本组织原理是什么？

合成生物学面临的主要挑战之一是从其组成部分重建生命系统。一个特别困难的里程碑是重建一个可以进行自主染色体紧缩，分离和细胞分裂的自组织系统。在这里，我们讨论syn3.0最小基因组如何使我们了解活细胞的核心自组织原理，以及如何自下而上构建这些自组织过程。该评论强调了基础生物学在从其分子成分重建生命中的重要性。

更新日期：2019-08-08

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