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Four Yellow Monoterpenoid Quinoline Alkaloids from the Stem of Tabernaemontana bovina.
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-10 00:00:00 , DOI: 10.1021/acs.orglett.9b01453 Jing Wu 1, 2 , Yang Yu 1, 2 , Yi Wang 3 , Mei-Fen Bao 1 , Bao-Bao Shi 1, 2 , Johann Schinnerl 4 , Xiang-Hai Cai 1
Organic Letters ( IF 4.9 ) Pub Date : 2019-06-10 00:00:00 , DOI: 10.1021/acs.orglett.9b01453 Jing Wu 1, 2 , Yang Yu 1, 2 , Yi Wang 3 , Mei-Fen Bao 1 , Bao-Bao Shi 1, 2 , Johann Schinnerl 4 , Xiang-Hai Cai 1
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Four unprecedented yellow alkaloids named as taberbovines A–D (1–4) were isolated from stems of Tabernaemontana bovina Lour. Their structures were elucidated by the comprehensive spectroscopic data, computational chemistry, and X-ray crystal diffraction. Alkaloids 1–4 possessed a unique 6/6/5/6/5 ring system and were assigned to monoterpenoid quinolines. Biosynthetically, the isolated alkaloids may be derived from Aspidosperma-type alkaloid by oxidation and rearrangements. Taberbovines A–D exhibited the good inhibitory activities of formation NO in LPS induced RAW264.7 macrophages.
中文翻译：
四种来自Tabernaemontana bovina茎的黄色单萜类喹啉生物碱。
命名为taberbovines A-d的四个前所未有黄色生物碱（1 - 4）中分离从茎的狗牙花属bovina LOUR。通过全面的光谱数据，计算化学和X射线晶体衍射阐明了它们的结构。生物碱1 - 4所具有的独特的6/6/5/6/5环系统和被分配到单萜喹啉。在生物合成上，分离的生物碱可以通过氧化和重排衍生自曲霉属生物碱。Taberbovines A–D在LPS诱导的RAW264.7巨噬细胞中表现出良好的NO形成抑制活性。
更新日期：2019-06-10
中文翻译：
四种来自Tabernaemontana bovina茎的黄色单萜类喹啉生物碱。
命名为taberbovines A-d的四个前所未有黄色生物碱（1 - 4）中分离从茎的狗牙花属bovina LOUR。通过全面的光谱数据，计算化学和X射线晶体衍射阐明了它们的结构。生物碱1 - 4所具有的独特的6/6/5/6/5环系统和被分配到单萜喹啉。在生物合成上，分离的生物碱可以通过氧化和重排衍生自曲霉属生物碱。Taberbovines A–D在LPS诱导的RAW264.7巨噬细胞中表现出良好的NO形成抑制活性。
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