Renal Denervation Update From the International Sympathetic Nervous System Summit,Journal of the American College of Cardiology

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Renal Denervation Update From the International Sympathetic Nervous System Summit
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2019-06-01 , DOI: 10.1016/j.jacc.2019.04.015
Márcio G Kiuchi ₁ , Murray D Esler ₂ , Gregory D Fink ₃ , John W Osborn ₄ , Christopher T Banek ₄ , Michael Böhm ₅ , Kate M Denton ₆ , Gerald F DiBona ₇ , Thomas H Everett ₈ , Guido Grassi ₉ , Richard E Katholi ₁₀ , Mark M Knuepfer ₁₁ , Ulla C Kopp ₁₂ , David J Lefer ₁₃ , Thomas E Lohmeier ₁₄ , Clive N May ₁₅ , Felix Mahfoud ₅ , Julian F R Paton ₁₆ , Roland E Schmieder ₁₇ , Peter R Pellegrino ₁₈ , Yehonatan Sharabi ₁₉ , Markus P Schlaich ₂₀

Affiliation

Dobney Hypertension Centre, School of Medicine-Royal Perth Hospital Unit, University of Western Australia and Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Australia.
Neurovascular Hypertension & Kidney Disease Laboratory and Human Neurotransmitter Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.
Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Saarland University, Homburg/Saar, Germany.
Cardiovascular Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Victoria, Australia.
Department of Internal Medicine and Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine, Iowa City, Iowa.
The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Prairie Heart Institute at St. John's Hospital, Department of Cardiology, Springfield, Illinois.
Department of Pharmacology and Physiology, St. Louis University School of Medicine, St. Louis, Missouri.
Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Science Center, New Orleans, Louisiana.
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Missouri.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences, University of Bristol, Bristol, United Kingdom.
Department of Nephrology and Hypertension, University Hospital of the University Erlangen-Nuremberg, Erlangen, Germany.
Departments of Anesthesiology and Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska.
Chaim Sheba Medical Center and Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel.
Dobney Hypertension Centre, School of Medicine-Royal Perth Hospital Unit, University of Western Australia and Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Australia; Neurovascular Hypertension & Kidney Disease Laboratory and Human Neurotransmitter Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.

Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.

中文翻译：

来自国际交感神经系统峰会的肾去神经支配更新

最近在未接受药物治疗和接受药物治疗的高血压患者中进行的三项肾去神经支配研究表明，与各自的假手术对照组相比，动态血压显着降低。改进的试验设计、相关患者队列的选择和优化的介入程序可能促成了这些积极的发现。然而，仍然可以观察到血压对肾脏去神经支配反应的显着变异性，并且仍然是一个具有挑战性和重要的问题。召开国际交感神经系统峰会，汇集实验和临床医学专家，讨论当前的证据基础、我们对神经相互作用、程序方面、技术成功监测等方面的理解的新进展。

更新日期：2019-06-01

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