Total Synthesis of Clavosolide A via Asymmetric Alcohol-Mediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction.,Angewandte Chemie International Edition

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Total Synthesis of Clavosolide A via Asymmetric Alcohol-Mediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-06-24 , DOI: 10.1002/anie.201906259
James M Cabrera ₁ , Michael J Krische ₁

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The 20‐membered marine macrodiolide clavosolide A is prepared in 7 steps (LLS) in the absence of protecting groups or chiral auxiliaries via enantioselective alcohol‐mediated carbonyl addition. In 9 prior total syntheses, 11–34 steps (LLS) were required.

中文翻译：

通过不对称醇介导的羰基烯丙基化全合成 Clavosolide A：超越聚酮化合物结构中的保护基团或手性助剂。

20 元海洋大二内酯 clavosolide A 在没有保护基团或手性助剂的情况下，通过对映选择性醇介导的羰基加成，经过 7 个步骤 (LLS) 制备。在之前的 9 次全合成中，需要 11-34 个步骤 (LLS)。

更新日期：2019-06-24

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