Mediator and Additive Free Trifluoromethyl‐Fluorination of Terminal Alkenes by Persistent Perfluoroalkyl Radical,European Journal of Organic Chemistry

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Mediator and Additive Free Trifluoromethyl‐Fluorination of Terminal Alkenes by Persistent Perfluoroalkyl Radical
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2019-06-25 , DOI: 10.1002/ejoc.201900651
Azusa Sato ₁ , Maksym V. Ponomarenko ₂ , Taizo Ono ₃ , Gerd-Volker Röschenthaler ₂ , Vadim A. Soloshonok _{4,

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Affiliation

The dual reactivity of the persistent perfluoro‐3‐ethyl‐2,4‐dimethyl‐3‐pentyl radical (PPFR) allows for both trifluoromethylation and fluorination of terminal olefins. This new approach towards di‐functionalized 1‐CF₃‐2‐F‐alkanes demonstrates the widespread synthetic potential.